Literature DB >> 6270384

Varicella-zoster virus vaccine DNA differs from the parental virus DNA.

J R Ecker, R W Hyman.   

Abstract

The DNAs of a varicella-zoster virus vaccine and its parental virus were compared by CsCl buoyant density centrifugation and restriction enzyme cleavage analysis. The varicella-zoster virus vaccine DNA showed a heterogeneous buoyant profile and altered restriction enzyme cleavage patterns. These changed properties are probably the result of the accumulation of virus containing defective varicella-zoster virus DNA during extensive cell culture passage of the vaccine virus.

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Year:  1981        PMID： 6270384      PMCID： PMC256623     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  24 in total

1.  Analysis of DNA of defective herpes simplex virus type 1 by restriction endonuclease cleavage and nucleic acid hybridization.

Authors:  M Wagner; J Skare; W C Summers
Journal:  Cold Spring Harb Symp Quant Biol       Date:  1975

2.  Anatomy of herpes simplex virus DNA. III. Characterization of defective DNA molecules and biological properties of virus populations containing them.

Authors:  N Frenkel; R J Jacob; R W Honess; G S Hayward; H Locker; B Roizman
Journal:  J Virol       Date:  1975-07       Impact factor: 5.103

3.  Equine herpesvirus in vivo: cyclic production of a DNA density variant with repetitive sequences.

Authors:  D E Campbell; M C Kemp; M L Perdue; C C Randall; G A Gentry
Journal:  Virology       Date:  1976-02       Impact factor: 3.616

4.  Detection of specific sequences among DNA fragments separated by gel electrophoresis.

Authors:  E M Southern
Journal:  J Mol Biol       Date:  1975-11-05       Impact factor: 5.469

5.  Development of a live attenuated varicella vaccine.

Authors:  M Takahashi; Y Okuno; T Otsuka; J Osame; A Takamizawa
Journal:  Biken J       Date:  1975-03

6.  Protection against varicella in family contacts by immediate inoculation with live varicella vaccine.

Authors:  Y Asano; H Nakayama; T Yazaki; R Kato; S Hirose
Journal:  Pediatrics       Date:  1977-01       Impact factor: 7.124

7.  Characterization of defective interfering viral particles present in a population of pseudorabies virions.

Authors:  T Ben-Porat; J M Demarchi; A S Kaplan
Journal:  Virology       Date:  1974-09       Impact factor: 3.616

8.  Defective virions of herpes simplex viruses.

Authors:  D L Bronson; G R Dreesman; N Biswal; M Benyesh-Melnick
Journal:  Intervirology       Date:  1973       Impact factor: 1.763

9.  The characterization of Varicella-zoster virus DNA.

Authors:  H Ludwig; H G Haines; N Biswal; M Benyesh-Melnick
Journal:  J Gen Virol       Date:  1972-01       Impact factor: 3.891

10.  Size, composition, and structure of the deoxyribonucleic acid of herpes simplex virus subtypes 1 and 2.

Authors:  E D Kieff; S L Bachenheimer; B Roizman
Journal:  J Virol       Date:  1971-08       Impact factor: 5.103
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  3 in total

1.  Varicella zoster virus DNA exists as two isomers.

Authors:  J R Ecker; R W Hyman
Journal:  Proc Natl Acad Sci U S A       Date:  1982-01       Impact factor: 11.205

2.  Characterization of guinea pig cytomegalovirus DNA.

Authors:  H C Isom; M Gao; B Wigdahl
Journal:  J Virol       Date:  1984-02       Impact factor: 5.103

3.  Errant processing and structural alterations of genomes present in a varicella-zoster virus vaccine.

Authors:  D A Vlazny; R W Hyman
Journal:  J Virol       Date:  1985-10       Impact factor: 5.103
  3 in total

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