Literature DB >> 6270361

Demonstration of avian sarcoma virus-coded pp60src in vivo and the anti-pp60src immune response in chickens.

M Ellwart-Tschürtz, R Kurth.   

Abstract

The avian sarcoma virus (ASV)-coded transforming protein pp60src was originally detected in vitro in ASV-transformed avian and mammalian cells in experiments involving mammalian antisera to ASV-induced tumors. It is demonstrated here that pp60src is also expressed in vivo in ASV tumors of chickens. Furthermore, the existence of the endogenous pp60src in all chicken cells does not impair the immune response to exogenous pp60src in the chicken. Whereas chicken antibodies can bind to pp60src, they do not serve as substrates for the protein kinase activity of this transforming protein.

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Year:  1981        PMID： 6270361      PMCID： PMC171329     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  8 in total

1.  Rapid isolation of antigens from cells with a staphylococcal protein A-antibody adsorbent: parameters of the interaction of antibody-antigen complexes with protein A.

Authors:  S W Kessler
Journal:  J Immunol       Date:  1975-12       Impact factor: 5.422

2.  Evidence that a precursor glycoprotein is cleaved to yield the major glycoprotein of avian tumor virus.

Authors:  J M England; D P Bolognesi; B Dietzschold; M S Halpern
Journal:  J Virol       Date:  1977-02       Impact factor: 5.103

3.  Intracellular precursors to the major glycoprotein of avian oncoviruses in chicken embryo fibroblasts.

Authors:  D L Buchhagen; H Hanafusa
Journal:  J Virol       Date:  1978-03       Impact factor: 5.103

4.  Cleavage of structural proteins during the assembly of the head of bacteriophage T4.

Authors:  U K Laemmli
Journal:  Nature       Date:  1970-08-15       Impact factor: 49.962

5.  Phosphorylating proteins as effectors in malignant cell transformation.

Authors:  R Kurth; J Stegmann; T Tanaka; J Löwer; H Frank
Journal:  Adv Cyclic Nucleotide Res       Date:  1981

Review 6.  The biosynthesis of oncovirus proteins.

Authors:  R N Eisenman; V M Vogt
Journal:  Biochim Biophys Acta       Date:  1978-04-06

7.  The immune response against the ASV-coded src-gene product in syngeneic mice.

Authors:  A Huesgen; G Huesgen; J Stegmann; R Kurth
Journal:  J Gen Virol       Date:  1980-06       Impact factor: 3.891

Review 8.  Molecular events in cells transformed by Rous Sarcoma virus.

Authors:  R L Erikson; A F Purchio; E Erikson; M S Collett; J S Brugge
Journal:  J Cell Biol       Date:  1980-11       Impact factor: 10.539
  8 in total
  1 in total

1.  src- and fps-containing avian sarcoma viruses transform chicken erythroid cells.

Authors:  P Kahn; B Adkins; H Beug; T Graf
Journal:  Proc Natl Acad Sci U S A       Date:  1984-11       Impact factor: 11.205
  1 in total

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