Literature DB >> 6269903

Anabolic steroids are fool's gold.

A J Ryan.   

Abstract

Since increases in muscle strength are proportional to increases in the cross-sectional diameter of the muscles being trained, the body must convert greater than normal amounts of amino acids available to it to increase size in athletes in training. When androgens became available in the 1930's they were used primarily to restore positive nitrogen balance in victims of starvation. Anabolic steroids, which were developed to avoid unwanted effects of androgens, were first given to weight lifters, but football players and weight throwers were soon using them. From 1965 to 1977, 25 clinical studies were published dealing with the administration of an anabolic-androgenic steroid to adult human males for evaluating changes in strength and, in 10 of these studies, in maximum oxygen consumption. In 12 of these studies, improvements were claimed from the use of these steroids; in the other 13 no improvements were observed. Other studies have shown that in healthy adult males these steroids reduce testosterone and gonadotrophin output, which reduces spermatogenesis. Alterations of normal liver function have been found in up to 80% of persons treated with C17-alkylated testosterone derivatives. Peliosis hepatitis, with liver failure and death, and fatal liver cancer have also been reported in adults so treated. Reliable methods for detecting anabolic steroids in the urine are now used in certain international competitions. Testing, announced bans, and disqualifications have not been effective in controlling the use of the drugs. The best hope for doing so lies in continuing education of athletes and their supervisors.

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Year:  1981        PMID: 6269903

Source DB:  PubMed          Journal:  Fed Proc        ISSN: 0014-9446


  11 in total

Review 1.  Enhancement of athletic performance with drugs. An overview.

Authors:  J C Wagner
Journal:  Sports Med       Date:  1991-10       Impact factor: 11.136

Review 2.  Psychological and behavioural effects of endogenous testosterone levels and anabolic-androgenic steroids among males. A review.

Authors:  M S Bahrke; C E Yesalis; J E Wright
Journal:  Sports Med       Date:  1990-11       Impact factor: 11.136

Review 3.  Epidemiological and policy issues in the measurement of the long term health effects of anabolic-androgenic steroids.

Authors:  C E Yesalis; J E Wright; M S Bahrke
Journal:  Sports Med       Date:  1989-09       Impact factor: 11.136

4.  Effects of an anabolic hormone on striated muscle growth and performance.

Authors:  S Egginton
Journal:  Pflugers Arch       Date:  1987-11       Impact factor: 3.657

5.  Androgenic steroid effects on liver and red cells.

Authors:  M Alén
Journal:  Br J Sports Med       Date:  1985-03       Impact factor: 13.800

Review 6.  Adverse effects of anabolic steroids.

Authors:  R C Hickson; K L Ball; M T Falduto
Journal:  Med Toxicol Adverse Drug Exp       Date:  1989 Jul-Aug

7.  Effects of anabolic steroids and high intensity exercise on rat skeletal muscle fibres and capillarization. A morphometric study.

Authors:  J Dimauro; R J Balnave; C D Shorey
Journal:  Eur J Appl Physiol Occup Physiol       Date:  1992

8.  Methandrostenolone: metabolism in the rabbit.

Authors:  J F Templeton; C C Jackson; J W Steele
Journal:  Eur J Drug Metab Pharmacokinet       Date:  1984 Jul-Sep       Impact factor: 2.441

Review 9.  Do fat supplements increase physical performance?

Authors:  Filippo Macaluso; Rosario Barone; Patrizia Catanese; Francesco Carini; Luigi Rizzuto; Felicia Farina; Valentina Di Felice
Journal:  Nutrients       Date:  2013-02-07       Impact factor: 5.717

10.  Mitochondrial function in diaphragm of emphysematous hamsters after treatment with nandrolone.

Authors:  Hanneke J H Wijnhoven; Leo Ennen; Richard J T Rodenburg; P N Richard Dekhuijzen
Journal:  Int J Chron Obstruct Pulmon Dis       Date:  2006
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