Literature DB >> 6269182

Hindbrain GABA receptors influence parasympathetic outflow to the stomach.

D J Williford, H S Ormsbee, W Norman, J W Harmon, T Q Garvey, J A DiMicco, R A Gillis.   

Abstract

Blockade of gamma-aminobutyric acid receptor function by direct microinjection of bicuculline into the nucleus ambiguous in cats produced a marked increase in gastric motility which was mediated by the vagus nerve. This effect was reversed by muscimol. These data indicate that the nucleus ambiguous may be an important brain site influencing gastric function and that the neurotransmitter controlling parasympathetic overflow from this nucleus to the stomach is gamma-aminobutyric acid.

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Year:  1981        PMID： 6269182     DOI： 10.1126/science.6269182

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  7 in total

Review 1.  Brainstem circuits regulating gastric function.

Authors:  R Alberto Travagli; Gerlinda E Hermann; Kirsteen N Browning; Richard C Rogers
Journal:  Annu Rev Physiol       Date:  2006       Impact factor: 19.318

2.  Influence of acoustic stress by noise on gastrointestinal motility in dogs.

Authors:  M Gue; J Fioramonti; J Frexinos; M Alvinerie; L Bueno
Journal:  Dig Dis Sci       Date:  1987-12       Impact factor: 3.199

3.  Brain stem as a target site for the metabolic side effects of olanzapine.

Authors:  Imran J Anwar; Kayoko Miyata; Andrea Zsombok
Journal:  J Neurophysiol       Date:  2015-12-30       Impact factor: 2.714

4.  CNS site of action and brainstem circuitry responsible for the intravenous effects of nicotine on gastric tone.

Authors:  Manuel Ferreira; Niaz Sahibzada; Min Shi; William Panico; Mark Niedringhaus; Adam Wasserman; Kenneth J Kellar; Joseph Verbalis; Richard A Gillis
Journal:  J Neurosci       Date:  2002-04-01       Impact factor: 6.167

5.  GABA-mimetic effect on gastric acid secretion. Possible significance in central mechanisms.

Authors:  Y Goto; H T Debas
Journal:  Dig Dis Sci       Date:  1983-01       Impact factor: 3.199

6.  Modulation of the vagal drive to the intramural cholinergic and non-cholinergic neurones in the ferret stomach by baclofen.

Authors:  P L Andrews; S Bingham; K L Wood
Journal:  J Physiol       Date:  1987-07       Impact factor: 5.182

7.  Impact of improvement of sleep disturbance on symptoms and quality of life in patients with functional dyspepsia.

Authors:  Fumihiko Nakamura; Shiko Kuribayashi; Fumio Tanaka; Noriyuki Kawami; Yasuhiro Fujiwara; Katsuhiko Iwakiri; Motoyasu Kusano; Toshio Uraoka
Journal:  BMC Gastroenterol       Date:  2021-02-18       Impact factor: 3.067
  7 in total

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