Sympathetic nerve terminal destruction has no effect on specific [3H]ouabain binding to intact mouse and rat skeletal muscle.

Following pretreatment with 6-OH-dopamine, the sympathetic nerve endings of the iris and skeletal muscle of mice and rats were not longer detectable by cytochemistry for noradrenaline. In the same animals, the specific binding of [3H] ouabain to intact soleus muscles was not significantly different from that measured in controls, Neither ouabain-suppressible 42K uptake nor Na-K contents were affected by chemical sympathectomy.