Literature DB >> 6268135

Lymphocytes infiltrating human breast cancers lack K-cell activity and show low levels of NK-cell activity.

O Eremin, R R Coombs, J Ashby.   

Abstract

Lymphocytes infiltrating human primary mammary carcinomas lack ADCC and show low levels of natural cytotoxicity. The peripheral blood lymphocytes, however, show a variable but prominent level of cytotoxicity. Lymphocyte preparations from breast tumours, when mixed with autologous blood lymphocytes, significantly suppress their prominent killer- (K- and NK-) cell activities.

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Year:  1981        PMID： 6268135      PMCID： PMC2010737          DOI： 10.1038/bjc.1981.167

Source DB:  PubMed          Journal:  Br J Cancer        ISSN： 0007-0920            Impact factor:   7.640


  26 in total

1.  Killer cell (K) activity in human normal lymph node, regional tumour lymph node and inflammatory lymph node.

Authors:  O Eremin; J Ashby; D Franks
Journal:  Int Arch Allergy Appl Immunol       Date:  1977

2.  Characterization of the human natural killer (NK) cell in blood and lymphoid organs.

Authors:  O Eremin; R R Coombs; D Plumb; J Ashby
Journal:  Int J Cancer       Date:  1978-01-15       Impact factor: 7.396

3.  Surface characteristics of the human K (killer) lymphocyte.

Authors:  O Eremin; D Kraft; R R Coombs; D Franks; J Ashby; D Plumb
Journal:  Int Arch Allergy Appl Immunol       Date:  1977

4.  The control of autoreactivity. I. Lack of autoreactivity in murine spleens is due to concomitant presence of suppressor and autocytotoxic lymphocytes.

Authors:  M Osband; R Parkman
Journal:  J Immunol       Date:  1978-07       Impact factor: 5.422

5.  Antibody-dependent cellular cytotoxicity and natural cytotoxicity: effect of pre-treatment of human lymphocytes with deionised water and ammonium chloride.

Authors:  O Eremin; J Ashby; D Plumb
Journal:  J Immunol Methods       Date:  1978       Impact factor: 2.303

6.  Immunologic factors influencing the intra-tumor localization of ADCC effector cells.

Authors:  S Haskill; E Parthenais
Journal:  J Immunol       Date:  1978-06       Impact factor: 5.422

7.  Human natural cytotoxicity in the blood and lymphoid organs of healthy donors and patients with malignant disease.

Authors:  O Eremin; J Ashby; J P Stephens
Journal:  Int J Cancer       Date:  1978-01-15       Impact factor: 7.396

8.  Possible host resistance in carcinoma of the breast: a histological study.

Authors:  I M Hamlin
Journal:  Br J Cancer       Date:  1968-09       Impact factor: 7.640

9.  Immunological significance of the morphological changes in lymph nodes draining breast cancer.

Authors:  O T Anastassiades; D M Pryce
Journal:  Br J Cancer       Date:  1966-06       Impact factor: 7.640

10.  Migratory behavior of lymphocytes with specific reactivity to alloantigens. II. Selective recruitment to lymphoid cell allografts and their draining lymph nodes.

Authors:  E E Emeson
Journal:  J Exp Med       Date:  1978-01-01       Impact factor: 14.307
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  25 in total

1.  Recombinant interleukin-2 treatment in patients with metastatic colorectal cancer: effect on natural cytotoxicity.

Authors:  K G Park; S D Heys; J B Murray; P D Hayes; J A Ashby; C R Franks; O Eremin
Journal:  Cancer Immunol Immunother       Date:  1992       Impact factor: 6.968

Review 2.  The biology of the human natural killer cell.

Authors:  J C Roder; H F Pross
Journal:  J Clin Immunol       Date:  1982-10       Impact factor: 8.317

Review 3.  Manipulation of host resistance in cancer therapy.

Authors:  R W Baldwin
Journal:  Springer Semin Immunopathol       Date:  1982

4.  Clonal analysis and in situ characterization of lymphocytes infiltrating human breast carcinomas.

Authors:  T L Whiteside; S Miescher; J Hurlimann; L Moretta; V von Fliedner
Journal:  Cancer Immunol Immunother       Date:  1986       Impact factor: 6.968

5.  Lymphoreticular infiltrates in invasive ductal breast cancer. A histological and immunohistological study.

Authors:  H P Horny; H A Horst
Journal:  Virchows Arch A Pathol Anat Histopathol       Date:  1986

6.  Tumor infiltrating lymphocytes of spontaneous versus transplanted mouse mammary tumors.

Authors:  W Z Wei; G H Heppner
Journal:  Cancer Immunol Immunother       Date:  1988       Impact factor: 6.968

7.  Native and inducible levels of natural cytotoxicity in lymph nodes draining mammary carcinoma.

Authors:  I Kimber; M Moore; A Howell; M J Wilkinson
Journal:  Cancer Immunol Immunother       Date:  1983       Impact factor: 6.968

8.  Expression and prognostic significance of HLA class I, ICAM-1, and tumor-infiltrating lymphocytes in esophageal cancer.

Authors:  S B Hosch; A J Meyer; C Schneider; N Stoecklein; K L Prenzel; K Pantel; C E Broelsch; J R Izbicki
Journal:  J Gastrointest Surg       Date:  1997 Jul-Aug       Impact factor: 3.452

9.  Potential role of natural killer cells in controlling tumorigenesis by human T-cell leukemia viruses.

Authors:  G Feuer; S A Stewart; S M Baird; F Lee; R Feuer; I S Chen
Journal:  J Virol       Date:  1995-02       Impact factor: 5.103

10.  CD4+ T lymphocytes infiltrating human breast cancer recognise autologous tumor in an MHC-class-II restricted fashion.

Authors:  R Dadmarz; M K Sgagias; S A Rosenberg; D J Schwartzentruber
Journal:  Cancer Immunol Immunother       Date:  1995-01       Impact factor: 6.968
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