Literature DB >> 6266847

Interaction of anticonvulsants with the barbiturate-benzodiazepine-GABA receptor complex.

F Leeb-Lundberg, A Snowman, R W Olsen.   

Abstract

Unlike the anesthetic barbiturate pentobarbital and the anxiolytic pyrazolopyridine etazolate, which enhance [3H]diazepam binding to rat brain membranes, the anticonvulsant barbiturates phenobarbital and metharbital, and also chlormethiazole, at therapeutic concentrations (10-1000 muM), do not stimulate [3H]diazepam binding, but instead block the enhancement by both pentobarbital and etazolate. The same anticonvulsants at similar concentrations inhibit [3H]alpha-dihydropicrotoxinin (DHP) binding suggesting that these anticonvulsants compete for the same receptor sites as pentobarbital and etazolate, designated the barbiturate-picrotoxinin receptor component of the benzodiazepine-GABA receptor complex.

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Year:  1981        PMID： 6266847     DOI： 10.1016/0014-2999(81)90309-5

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  6 in total

1.  Evidence that clomethiazole interacts with the macromolecular GABA A-receptor complex in the central nervous system and in the anterior pituitary gland.

Authors:  M Vincens; A Enjalbert; K G Lloyd; J J Paillard; F Thuret; C Kordon; P Lechat
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1989-04       Impact factor: 3.000

2.  The modulation by chlormethiazole of the GABAA-receptor complex in rat brain.

Authors:  A J Cross; J M Stirling; T N Robinson; D M Bowen; P T Francis; A R Green
Journal:  Br J Pharmacol       Date:  1989-09       Impact factor: 8.739

3.  Modulation of specific [3H]phenytoin binding by benzodiazepines.

Authors:  L Spero
Journal:  Neurochem Res       Date:  1985-06       Impact factor: 3.996

Review 4.  The diversity of GABAA receptors. Pharmacological and electrophysiological properties of GABAA channel subtypes.

Authors:  W Hevers; H Lüddens
Journal:  Mol Neurobiol       Date:  1998-08       Impact factor: 5.590

5.  The effects of chlormethiazole on single unit activity in rat brain; interactions with inhibitory and excitatory neurotransmitters.

Authors:  J P Gent; T A Wacey
Journal:  Br J Pharmacol       Date:  1983-11       Impact factor: 8.739

6.  Two distinct interactions of barbiturates and chlormethiazole with the GABAA receptor complex in rat cuneate nucleus in vitro.

Authors:  N L Harrison; M A Simmonds
Journal:  Br J Pharmacol       Date:  1983-10       Impact factor: 8.739
  6 in total

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