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Literature DB >> 6265918

Histone genes are clustered but not tandemly repeated in the chicken genome.

Abstract

The recombinant chicken DNA library was screened for histone genes by using pSp17, a recombinant sea urchin DNA probe containing the H2a and H3 genes of Strongylocentrotus purpuratus. Three of the isolated lambda recombinants have been analyzed by restriction enzyme mapping and Southern blotting; one histone H3 gene-encoding recombinant was further analyzed by DNA sequence determination. These studies reveal that the chicken histone genes are not tandemly reiterated, but that, at the least, several histone genes are physically closely linked in a nonrepetitive arrangement within the chicken genome. The evolutionary implications of this arrangement versus that seen in Drosophila and sea urchins is discussed.

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Year: 1981 PMID： 6265918 PMCID： PMC319457 DOI： 10.1073/pnas.78.5.2856

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

22 in total

Histone genes are clustered but not tandemly repeated in the chicken genome.

1. Histone gene arrangement in the sea urchin, Strongylocentrotus purpuratus.

2. Chain length determination of small double- and single-stranded DNA molecules by polyacrylamide gel electrophoresis.

3. Ligation of EcoRI endonuclease-generated DNA fragments into linear and circular structures.

4. The programmed switch in lysine-rich histone synthesis at gastrulation.

5. Histone-gene reiteration in the genome of mouse.

6. Reiteration frequency of histone coding sequences in man.

7. Reiteration and clustering of DNA sequences complementary to histone messenger RNA.

8. A simple method for DNA restriction site mapping.

9. Reiteration frequency of the gene for tissue-specific histone H5 in the chicken genome.

10. Nucleotide sequence of the rightward operator of phage lambda.

1. Isolation and characterization of a Drosophila hydei histone DNA repeat unit.

2. Cloning and characterization of a core histone gene tandem repeat in Urechis caupo.

3. Chromosomal organization of chicken histone genes: preferred associations and inverted duplications.

4. Sequences of four mouse histone H3 genes: implications for evolution of mouse histone genes.

5. On the origins of tandemly repeated genes: does histone gene copy number in Drosophila reflect chromosomal location?

6. Replacement variant histone genes contain intervening sequences.

7. Tetrahymena H4 genes: structure, evolution and organization in macro- and micronuclei.

8. Organization and expression of cloned histone gene clusters from Xenopus laevis and X. borealis.

9. Histone gene number and organisation in Xenopus: Xenopus borealis has a homogeneous major cluster.

10. Characterization of histone genes isolated from Xenopus laevis and Xenopus tropicalis genomic libraries.