Literature DB >> 6265382

Herpesvirus saimiri: protective effect of attenuated strain against lymphoma induction.

J Wright, L A Falk, L G Wolfe, F Deinhardt.   

Abstract

An attenuated strain of Herpesvirus saimiri (A-HVS) induced a persistent, latent infection in common marmosets. Virus was recovered from circulating lymphocytes of infected animals and antibody response to virus-specified antigens was demonstrated over 3-12 months PI. A-HVS-infected common marmosets and animals without previous A-HVS exposure were challenged with oncogenic HVS (125-825 PFU); marmosets without A-HVS infection developed malignant lymphoproliferative disease and died 3 weeks PI whereas all persistently-infected animals have survived 38-43 months post challenge.

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Year:  1980        PMID: 6265382     DOI: 10.1002/ijc.2910260413

Source DB:  PubMed          Journal:  Int J Cancer        ISSN: 0020-7136            Impact factor:   7.396


  3 in total

1.  Deletion of DNA sequence in a nononcogenic variant of Herpesvirus saimiri.

Authors:  J M Koomey; C Mulder; R L Burghoff; B Fleckenstein; R C Desrosiers
Journal:  J Virol       Date:  1984-05       Impact factor: 5.103

2.  Mapping of RNA transcribed from a region of the Herpesvirus saimiri genome required for oncogenicity.

Authors:  J Kamine; A Bakker; R C Desrosiers
Journal:  J Virol       Date:  1984-11       Impact factor: 5.103

3.  Construction of replication-competent Herpesvirus saimiri deletion mutants.

Authors:  R C Desrosiers; R L Burghoff; A Bakker; J Kamine
Journal:  J Virol       Date:  1984-02       Impact factor: 5.103

  3 in total

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