Literature DB >> 6265230

Prostacyclin prevents ischemia-induced increase of lactate and cyclic AMP in ischemic myocardium.

R Rösen, P Rösen, R Ohlendorf, K Schrör.   

Abstract

The effect of prostacyclin (PGI2, 0.5 nmol . kg-1 . min-1,i.v.) on myocardial metabolism was studied in cats subjected to 5 h of myocardial ischemia (MI) and compared to vehicle-treated MI cats. MI was followed by a 52% decrease in ATP and a concomitant increase (2-3 fold) in lactate and lactate/pyruvate ratio in the severely ischemic area. PGI2 prevented this increase in lactate with an unchanged ATP and lactate/pyruvate ratio. Moreover, PGI2 abolished the ischemia-induced in myocardial cAMP. It is concluded, the PGI2 exerts its beneficial actions on ischemic myocardium partly via cAMP-linked mechanisms.

Entities:  

Mesh：

Substances：

Year:  1981        PMID： 6265230     DOI： 10.1016/0014-2999(81)90454-4

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  7 in total

1.  Prostacyclin and iloprost: equal efficiency in preserving high energy phosphates in the dog heart following coronary artery ligation.

Authors:  M Pissarek; H Goos; J Nöhring; J Graff; G Buller; I Beyerdörfer; H J Mest; K F Lindenau; E G Krause
Journal:  Basic Res Cardiol       Date:  1987 Nov-Dec       Impact factor: 17.165

Review 2.  Significance of myocardial eicosanoid production.

Authors:  M van Bilsen; W Engels; G J van der Vusse; R S Reneman
Journal:  Mol Cell Biochem       Date:  1989 Jun 27-Jul 24       Impact factor: 3.396

3.  Effects of iloprost, a PGI2 derivative, on ischemic myocardial energy and carbohydrate metabolism in dogs.

Authors:  K Ichihara; K Yamamoto; Y Abiko
Journal:  Mol Cell Biochem       Date:  1993-02-17       Impact factor: 3.396

4.  Effect of prostacyclin infusion during low-flow ischaemia in the isolated perfused rat heart.

Authors:  W G Nayler; M Purchase; G J Dusting
Journal:  Basic Res Cardiol       Date:  1984 Mar-Apr       Impact factor: 17.165

5.  Effects of prostacyclin analogue, OP-2507, on function and metabolism in the ischemic working rat heart.

Authors:  T Oguchi; S Kashimoto; T Nakamura; T Kumazawa
Journal:  J Anesth       Date:  1992-10       Impact factor: 2.078

6.  Protective effect of prostaglandins D2, E1 and I2 against cerebral hypoxia/anoxia in mice.

Authors:  Y Masuda; Y Ochi; Y Ochi; T Karasawa; N Hatano; T Kadokawa; M Shimizu
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1986-11       Impact factor: 3.000

7.  Cardioprotective actions of pentoxifylline in an animal model of acute myocardial ischaemia.

Authors:  W Gallenkämper; W Rücker; K Schrör
Journal:  Br J Pharmacol       Date:  1984-04       Impact factor: 8.739
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.