Literature DB >> 6264606

Plasmid DNA in Treponema pallidum (Nichols): potential for antibiotic resistance by syphilis bacteria.

M V Norgard, J N Miller.   

Abstract

A plasmid DNA structure (approximate molecular weight = 7.5 X 10(6)) was identified in the human pathogen Treponema pallidum (Nichols). The inability to isolate this plasmid from rabbit host tissue and the total lack of DNA homology of the plasmid with rabbit DNA has confirmed its Treponema pallidum origin. The observation documents a newly recognized and potentially significant genetic capability for Treponema pallidum.

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Year:  1981        PMID： 6264606     DOI： 10.1126/science.6264606

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  16 in total

Review 1.  Syphilis: review with emphasis on clinical, epidemiologic, and some biologic features.

Authors:  A E Singh; B Romanowski
Journal:  Clin Microbiol Rev       Date:  1999-04       Impact factor: 26.132

2.  In vitro culture system to determine MICs and MBCs of antimicrobial agents against Treponema pallidum subsp. pallidum (Nichols strain).

Authors:  S J Norris; D G Edmondson
Journal:  Antimicrob Agents Chemother       Date:  1988-01       Impact factor: 5.191

3.  Treponema pallidum subsp. pallidum has a single, circular chromosome with a size of approximately 900 kilobase pairs.

Authors:  E M Walker; J K Arnett; J D Heath; S J Norris
Journal:  Infect Immun       Date:  1991-07       Impact factor: 3.441

4.  Yaws in Ecuador: impact of control measures on the disease in the Province of Esmeraldas.

Authors:  M Anselmi; E Araujo; A Narváez; P J Cooper; R H Guderian
Journal:  Genitourin Med       Date:  1995-12

5.  Cloning and expression of the major 47-kilodalton surface immunogen of Treponema pallidum in Escherichia coli.

Authors:  M V Norgard; N R Chamberlain; M A Swancutt; M S Goldberg
Journal:  Infect Immun       Date:  1986-11       Impact factor: 3.441

Review 6.  Antibacterial therapy of neurosyphilis: lack of impact of new therapies.

Authors:  Latisha Ali; Karen L Roos
Journal:  CNS Drugs       Date:  2002       Impact factor: 5.749

7.  Characterization of a circular plasmid from Borrelia burgdorferi, etiologic agent of Lyme disease.

Authors:  F W Hyde; R C Johnson
Journal:  J Clin Microbiol       Date:  1988-10       Impact factor: 5.948

8.  Monoclonal antibody selection and analysis of a recombinant DNA-derived surface immunogen of Treponema pallidum expressed in Escherichia coli.

Authors:  M A Swancutt; D A Twehous; M V Norgard
Journal:  Infect Immun       Date:  1986-04       Impact factor: 3.441

9.  Radioimmunoassays for the detection of antibodies to treponemal polypeptide antigens in serum.

Authors:  R E Baughn; D M Musher
Journal:  J Clin Microbiol       Date:  1985-06       Impact factor: 5.948

10.  In vitro assay to demonstrate high-level erythromycin resistance of a clinical isolate of Treponema pallidum.

Authors:  L V Stamm; J T Stapleton; P J Bassford
Journal:  Antimicrob Agents Chemother       Date:  1988-02       Impact factor: 5.191
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