Literature DB >> 6264597

Epidermal growth factors enhances viral transformation of granulosa cells.

J Harrison, N Auersperg.   

Abstract

Kirsten sarcoma virus produced a low incidence of transient morphological transformation in primary cultures of rat ovarian granulosa cells. In the presence of epidermal growth factor, the incidence of transient transformation increased severalfold and two continuous cell lines were established. Epidermal growth factor, a naturally occurring polypeptide hormone, appears to act here as a tumor promoter in the retrovirus-induced transformation of a mesodermally derived epithelium.

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Year:  1981        PMID： 6264597     DOI： 10.1126/science.6264597

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  6 in total

1.  Detection of an intracellular transforming protein (v-Ki-ras p21) using the flow activated cell sorter (FACS).

Authors:  D Freedman; N Auersperg
Journal:  In Vitro Cell Dev Biol       Date:  1986-10

2.  Expression of viral p21ras during acquisition of a transformed phenotype by rat adrenal cortex cells infected with Kirsten murine sarcoma virus.

Authors:  A MacAuley; N Auersperg; T Pawson
Journal:  Mol Cell Biol       Date:  1986-01       Impact factor: 4.272

3.  Growth stimulation and apoptosis induced in cultures of neonatal rat liver cells by repeated exposures to epidermal growth factor/urogastrone with or without associated pancreatic hormones.

Authors:  U Armato; F Romano; P G Andreis; L Paccagnella; C Marchesini
Journal:  Cell Tissue Res       Date:  1986       Impact factor: 5.249

4.  Evidence for the involvement of the submandibular gland epidermal growth factor in mouse mammary tumorigenesis.

Authors:  H Kurachi; S Okamoto; T Oka
Journal:  Proc Natl Acad Sci U S A       Date:  1985-09       Impact factor: 11.205

5.  Mitogenic hormones and tumor promoters greatly increase the incidence of colony-forming cells bearing amplified dihydrofolate reductase genes.

Authors:  J Barsoum; A Varshavsky
Journal:  Proc Natl Acad Sci U S A       Date:  1983-09       Impact factor: 11.205

6.  Genome structure of mink cell focus-forming murine leukemia virus in epithelial mink lung cells transformed vitro by iododeoxyuridine-induced C3H/MuLV cells.

Authors:  U R Rapp; E Birkenmeier; T I Bonner; M A Gonda; M Gunnell
Journal:  J Virol       Date:  1983-02       Impact factor: 5.103
  6 in total

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