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Literature DB >> 6264127

Organization of viral genome in a T antigen-negative hamster tumor induced by human papovavirus BK.

Abstract

We analyzed by blot hybridization the state and structure of the viral DNA in an exceptional BK virus-induced hamster tumor (choroid plexus papilloma Vn-324) that contains about one copy of the BK virus genome per cell, but no intranuclear T antigen as assayed by indirect immunofluorescence. The BK viral DNA was found to be integrated into cellular DNA at a site in the middle of the early region of the viral genome (between 0.32 and 0.41 map units). The structure of the inserted viral DNA shows that it cannot encode a full-size large T antigen, but may encode small T antigen and an N-terminal portion of large T antigen.

Entities: CellLine Disease Species

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Year: 1981 PMID： 6264127 PMCID： PMC171186

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

26 in total

1. Infectivity, oncogenicity and transforming ability of BK virus and BK virus DNA.

Authors: J van der Noordaa
Journal: J Gen Virol Date: 1976-03 Impact factor: 3.891

2. Detection of specific sequences among DNA fragments separated by gel electrophoresis.

Authors: E M Southern
Journal: J Mol Biol Date: 1975-11-05 Impact factor: 5.469

3. Transplantable hamster tumors induced with the BK virus.

Authors: L M Näse; M Kärkkäinen; R A Mäntyjärvi
Journal: Acta Pathol Microbiol Scand B Date: 1975-08

4. Sarcoma in a hamster inoculated with BK virus, a human papovavirus.

Authors: K V Shah; R W Daniel; J D Strandberg
Journal: J Natl Cancer Inst Date: 1975-04 Impact factor: 13.506

5. Isolation of high-molecular-weight DNA from mammalian cells.

Authors: M Gross-Bellard; P Oudet; P Chambon
Journal: Eur J Biochem Date: 1973-07-02

6. Physical map of the BK virus genome.

Authors: P M Howley; G Khoury; J C Byrne; K K Takemoto; M A Martin
Journal: J Virol Date: 1975-10 Impact factor: 5.103

7. Hamster ependymomas produced by intracerebral inoculation of a human papovavirus (MMV).

Authors: J Costa; C Yee; T S Tralka; A S Rabson
Journal: J Natl Cancer Inst Date: 1976-04 Impact factor: 13.506

8. A membrane-filter technique for the detection of complementary DNA.

Authors: D T Denhardt
Journal: Biochem Biophys Res Commun Date: 1966-06-13 Impact factor: 3.575

9. Induction of tumors in Syrian hamsters by a human renal papovavirus, RF strain.

Authors: R M Dougherty
Journal: J Natl Cancer Inst Date: 1976-08 Impact factor: 13.506

10. Presence of viral DNA sequences in hamster tumors induced by BK virus, a human papovavirus.

Authors: Y Yogo; R Hondo; S Uchida; S Watanabe; A Furuno; K Yoshiike
Journal: Microbiol Immunol Date: 1980 Impact factor: 1.955

7 in total

1. Sequence rearrangement in JC virus DNAs molecularly cloned from immunosuppressed renal transplant patients.

Authors: Y Yogo; T Kitamura; C Sugimoto; K Hara; T Iida; F Taguchi; A Tajima; K Kawabe; Y Aso
Journal: J Virol Date: 1991-05 Impact factor: 5.103

2. Interaction of K papovavirus with hamster cells: transformation of glial cells in vitro but failure of the virus to produce central nervous system tumors in vivo.

Authors: J E Greenlee; M F Law
Journal: Arch Virol Date: 1985 Impact factor: 2.574

3. Typing of human polyomavirus JC virus on the basis of restriction fragment length polymorphisms.

Authors: Y Yogo; T Iida; F Taguchi; T Kitamura; Y Aso
Journal: J Clin Microbiol Date: 1991-10 Impact factor: 5.948

Review 4. Papovaviral persistent infections.

Authors: L C Norkin
Journal: Microbiol Rev Date: 1982-12