Literature DB >> 6263396

Are fibre supplements really necessary in diverticular disease of the colon? A controlled clinical trial.

M H Ornstein, E R Littlewood, I M Baird, J Fowler, W R North, A G Cox.   

Abstract

Fifty-eight patients with uncomplicated diverticular disease of the colon took bran crispbread, ispaghula drink, and placebo for four months each in a randomised, cross-over, double-blind controlled trial. Assessments were made subjectively, using a monthly self-administered questionnaire, and objectively, by examining a seven-day stool collection at the end of each treatment period. In terms of a pain score, lower bowel symptom score (the pain score and sensation of incomplete emptying, straining, stool consistency, flatus, and aperients taken), and total symptom score (belching, nausea, vomiting, dyspepsia, and abdominal distension) fibre supplementation conferred no benefit. Symptoms of constipation, however, when assessed alone, were significantly relieved. Both fibre regimens produced the expected changes in stool weight, consistency, and frequency. It is concluded that dietary fibre supplements in the commonly used doses do no more than relieve constipation. Perhaps the impression that fibre helps diverticular disease is simply a manifestation of Western civilisation's obsession with the need for regular frequent defecation.

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Year:  1981        PMID: 6263396      PMCID: PMC1505006          DOI: 10.1136/bmj.282.6273.1353

Source DB:  PubMed          Journal:  Br Med J (Clin Res Ed)        ISSN: 0267-0623


  15 in total

1.  Changes in fecal composition and colonic function due to cereal fiber.

Authors:  J H Cummings; M J Hill; D J Jenkins; J R Pearson; H S Wiggins
Journal:  Am J Clin Nutr       Date:  1976-12       Impact factor: 7.045

2.  Bran tablets and diverticular disease.

Authors:  I Taylor; H L Duthie
Journal:  Br Med J       Date:  1976-04-24

3.  Effects of dietary supplements of wheat bran and cellulose on faeces and bowel function.

Authors:  M A Eastwood; J R Kirkpatrick; W D Mitchell; A Bone; T Hamilton
Journal:  Br Med J       Date:  1973-11-17

Review 4.  Diverticular disease of the colon: a deficiency disease of Western civilization.

Authors:  N S Painter; D P Burkitt
Journal:  Br Med J       Date:  1971-05-22

5.  Sterculia bulk-forming agent with smooth-muscle relaxant versus bran in diverticular disease.

Authors:  G S Srivastava; A N Smith; N S Painter
Journal:  Br Med J       Date:  1976-02-07

6.  Dietary management of diverticular disease.

Authors:  P F Plumley; B Francis
Journal:  J Am Diet Assoc       Date:  1973-11

7.  Unprocessed bran in treatment of diverticular disease of the colon.

Authors:  N S Painter; A Z Almeida; K W Colebourne
Journal:  Br Med J       Date:  1972-04-15

8.  Measurement of the mean transit time of dietary residue through the human gut.

Authors:  J H Cummings; D J Jenkins; H S Wiggins
Journal:  Gut       Date:  1976-03       Impact factor: 23.059

9.  Natural fiber and bowel dysfunction.

Authors:  A M Connell
Journal:  Am J Clin Nutr       Date:  1976-12       Impact factor: 7.045

10.  Diverticular disease: threee studies. Part II - Treatment with bran.

Authors:  A J Brodribb; D M Humphreys
Journal:  Br Med J       Date:  1976-02-21
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  32 in total

1.  Long-term treatment with mesalazine in patients with symptomatic uncomplicated diverticular disease.

Authors:  Luigi Gatta; Francesco Di Mario; Margherita Curlo; Dino Vaira; Alberto Pilotto; Paolo Lucarini; Maurizio Lera; Kajo Enkleda; Angelo Franzé; Carmelo Scarpignato
Journal:  Intern Emerg Med       Date:  2011-01-29       Impact factor: 3.397

Review 2.  The hot air and cold facts of dietary fibre.

Authors:  Carla S Coffin; Eldon A Shaffer
Journal:  Can J Gastroenterol       Date:  2006-04       Impact factor: 3.522

Review 3.  Management of diverticulitis.

Authors:  Simon E J Janes; Allan Meagher; Frank A Frizelle
Journal:  BMJ       Date:  2006-02-04

Review 4.  Physiology and pathophysiology of colonic motor activity (2).

Authors:  S K Sarna
Journal:  Dig Dis Sci       Date:  1991-07       Impact factor: 3.199

5.  Italian consensus conference for colonic diverticulosis and diverticular disease.

Authors:  Rosario Cuomo; Giovanni Barbara; Fabio Pace; Vito Annese; Gabrio Bassotti; Gian Andrea Binda; Tino Casetti; Antonio Colecchia; Davide Festi; Roberto Fiocca; Andrea Laghi; Giovanni Maconi; Riccardo Nascimbeni; Carmelo Scarpignato; Vincenzo Villanacci; Bruno Annibale
Journal:  United European Gastroenterol J       Date:  2014-10       Impact factor: 4.623

6.  Is bran efficacious in irritable bowel syndrome? A double blind placebo controlled crossover study.

Authors:  M R Lucey; M L Clark; J Lowndes; A M Dawson
Journal:  Gut       Date:  1987-02       Impact factor: 23.059

7.  The medical and nonoperative treatment of diverticulitis.

Authors:  Heath Beckham; Charles B Whitlow
Journal:  Clin Colon Rectal Surg       Date:  2009-08

8.  Prospective randomized clinical trial assessing the efficacy of a short course of intravenously administered amoxicillin plus clavulanic acid followed by oral antibiotic in patients with uncomplicated acute diverticulitis.

Authors:  Yolanda Ribas; Jordi Bombardó; Francesc Aguilar; Esther Jovell; Manel Alcantara-Moral; Francesc Campillo; Xavier Lleonart; Xavier Serra-Aracil
Journal:  Int J Colorectal Dis       Date:  2010-06-05       Impact factor: 2.571

Review 9.  Drug treatment of the irritable bowel syndrome.

Authors:  P L Pattee; W G Thompson
Journal:  Drugs       Date:  1992-08       Impact factor: 9.546

Review 10.  Diverticular disease. Epidemiology and pharmacological treatment.

Authors:  L J Cheskin; R D Lamport
Journal:  Drugs Aging       Date:  1995-01       Impact factor: 3.923

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