Proteins of herpesvirus saimiri: identification of two virus polypeptides released into the culture medium of productively infected cells.

Two virus-induced polypeptides are preferentially released into the culture medium of owl monkey kidney cells productively infected with herpesvirus saimiri (HVS). These polypeptides have apparent mol. wt. of 160 X 10(3) and 28 X 10(3) and are the major virus-induced polypeptides in a membrane fraction from infected cells. Both these excreted polypeptides co-migrate with virus structural proteins and are selectively released from enveloped virus particles by treatment with Nonidet-P40.