Literature DB >> 6261850

Relationship between presynaptic calcium current and postsynaptic potential in squid giant synapse.

R Llinás, I Z Steinberg, K Walton.   

Abstract

The relationship between calcium current and transmitter release was studied in squid giant synapse. It was found that the voltage-dependent calcium current triggers the release of synaptic transmitter in direct proportion to its magnitude and duration. Transmitter release occurs with a delay of approximately 200 mus after the influx of calcium. A model is presented which describes these relations formally.

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Year:  1981        PMID： 6261850      PMCID： PMC1327434          DOI： 10.1016/S0006-3495(81)84899-0

Source DB:  PubMed          Journal:  Biophys J        ISSN： 0006-3495            Impact factor:   4.033


  45 in total

1.  Movements of labelled calcium in squid giant axons.

Authors:  A L HODGKIN; R D KEYNES
Journal:  J Physiol       Date:  1957-09-30       Impact factor: 5.182

Review 2.  Intracellular and extracellular calcium ions in transmitter release at the neuromuscular synapse.

Authors:  R Rahamimoff; S D Erulkar; A Lev-Tov; H Meiri
Journal:  Ann N Y Acad Sci       Date:  1978-04-28       Impact factor: 5.691

Review 3.  The regulation of intracellular calcium in presynaptic nerve terminals.

Authors:  M P Blaustein; R W Ratzlaff; N K Kendrick
Journal:  Ann N Y Acad Sci       Date:  1978-04-28       Impact factor: 5.691

Review 4.  Organization of vertebrate retinas.

Authors:  J E Dowling
Journal:  Invest Ophthalmol       Date:  1970-09

5.  Presynaptic calcium currents in squid giant synapse.

Authors:  R Llinás; I Z Steinberg; K Walton
Journal:  Biophys J       Date:  1981-03       Impact factor: 4.033

6.  Uptake and binding of calcium by axoplasm isolated from giant axons of Loligo and Myxicola.

Authors:  P F Baker; W W Schlaepfer
Journal:  J Physiol       Date:  1978-03       Impact factor: 5.182

7.  The action of calcium on neuronal synapses in the squid.

Authors:  R Miledi; C R Slater
Journal:  J Physiol       Date:  1966-05       Impact factor: 5.182

8.  Presynaptic membrane potential affects transmitter release in an identified neuron in Aplysia by modulating the Ca2+ and K+ currents.

Authors:  E Shapiro; V F Castellucci; E R Kandel
Journal:  Proc Natl Acad Sci U S A       Date:  1980-01       Impact factor: 11.205

9.  Calcium buffering in presynaptic nerve terminals. I. Evidence for involvement of a nonmitochondrial ATP-dependent sequestration mechanism.

Authors:  M P Blaustein; R W Ratzlaff; N C Kendrick; E S Schweitzer
Journal:  J Gen Physiol       Date:  1978-07       Impact factor: 4.086

10.  Intracellular recording from the giant synapse of the squid.

Authors:  T H BULLOCK; S HAGIWARA
Journal:  J Gen Physiol       Date:  1957-03-20       Impact factor: 4.086
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  204 in total

1.  C2 domains from different Ca2+ signaling pathways display functional and mechanistic diversity.

Authors:  E A Nalefski; M A Wisner; J Z Chen; S R Sprang; M Fukuda; K Mikoshiba; J J Falke
Journal:  Biochemistry       Date:  2001-03-13       Impact factor: 3.162

2.  Formation and function of synapses with respect to Schwann cells at the end of motor nerve terminal branches on mature amphibian (Bufo marinus) muscle.

Authors:  G T Macleod; P A Dickens; M R Bennett
Journal:  J Neurosci       Date:  2001-04-01       Impact factor: 6.167

3.  Measurement of action potential-induced presynaptic calcium domains at a cultured neuromuscular junction.

Authors:  D A DiGregorio; A Peskoff; J L Vergara
Journal:  J Neurosci       Date:  1999-09-15       Impact factor: 6.167

4.  Effects of mobile buffers on facilitation: experimental and computational studies.

Authors:  Y Tang; T Schlumpberger; T Kim; M Lueker; R S Zucker
Journal:  Biophys J       Date:  2000-06       Impact factor: 4.033

5.  Syntaxin modulation of calcium channels in cortical synaptosomes as revealed by botulinum toxin C1.

Authors:  J B Bergsman; R W Tsien
Journal:  J Neurosci       Date:  2000-06-15       Impact factor: 6.167

6.  Ca2+ influx via the L-type Ca2+ channel during tail current and above current reversal potential in ferret ventricular myocytes.

Authors:  Z Zhou; D M Bers
Journal:  J Physiol       Date:  2000-02-15       Impact factor: 5.182

7.  Synaptic depression and the kinetics of exocytosis in retinal bipolar cells.

Authors:  J Burrone; L Lagnado
Journal:  J Neurosci       Date:  2000-01-15       Impact factor: 6.167

8.  Monte carlo simulation of 3-D buffered Ca(2+) diffusion in neuroendocrine cells.

Authors:  A Gil; J Segura; J A Pertusa; B Soria
Journal:  Biophys J       Date:  2000-01       Impact factor: 4.033

9.  The effects of baclofen on calcium channel currents in dorsal sensory cells of the spinal cord in the lamprey.

Authors:  I V Batueva; J T Buchanan; E A Tsvetkov; A K Sagatelyan; N P Veselkin
Journal:  Neurosci Behav Physiol       Date:  1999 Jan-Feb

10.  Molecular determinants of the functional interaction between syntaxin and N-type Ca2+ channel gating.

Authors:  I Bezprozvanny; P Zhong; R H Scheller; R W Tsien
Journal:  Proc Natl Acad Sci U S A       Date:  2000-12-05       Impact factor: 11.205
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