Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 GABA receptors are increased in brains of alcoholics.

Literature DB >> 6261673

GABA receptors are increased in brains of alcoholics.

V T Tran, S H Snyder, L F Major, R J Hawley.

Abstract

gamma-Aminobutyric acid (GABA) receptor binding was increased in postmortem brain samples of chronic alcoholic patients compared to control patients. Numbers of binding sites were augmented in alcoholic brain, with no change in affinity. Muscarinic cholinergic and benzodiazepine receptors did not differ between controls and alcoholic brains, while a modest reduction in beta-adrenergic receptors may have been related to postmortem receptor changes. The results suggest that GABAergic mechanisms might play a role in chronic alcoholism.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 1981 PMID： 6261673 DOI： 10.1002/ana.410090312

Source DB: PubMed Journal: Ann Neurol ISSN： 0364-5134 Impact factor: 10.422

Keyword Cloud
Cited

13 in total

Review 1. Neuroimaging insights into the role of cortical GABA systems and the influence of nicotine on the recovery from alcohol dependence.

Authors: Kelly P Cosgrove; Irina Esterlis; Graeme F Mason; Frederic Bois; Stephanie S O'Malley; John H Krystal
Journal: Neuropharmacology Date: 2011-01-27 Impact factor: 5.250

2. Quantitative trait loci involved in genetic predisposition to acute alcohol withdrawal in mice.

Authors: K J Buck; P Metten; J K Belknap; J C Crabbe
Journal: J Neurosci Date: 1997-05-15 Impact factor: 6.167

3. Advances in understanding alcohol withdrawal states.

Authors: F J Lichtigfeld; M A Gillman
Journal: Postgrad Med J Date: 1991-07 Impact factor: 2.401

4. Reduced motor cortex GABA_BR function following chronic alcohol exposure.

Authors: Shi-Yu Peng; Zhe Shi; Dong-Sheng Zhou; Xin-Yue Wang; Xing-Xing Li; Xiao-Li Liu; Wei-Di Wang; Guan-Ning Lin; Bing-Xing Pan; Valerie Voon; Anthony A Grace; Markus Heilig; Ma-Li Wong; Ti-Fei Yuan
Journal: Mol Psychiatry Date: 2021-01-11 Impact factor: 15.992

10. Lack of effect of the benzodiazepine antagonist flumazenil (Ro 15-1788) on the performance of healthy subjects during experimentally induced ethanol intoxication.

Authors: A Flückiger; D Hartmann; B Leishman; W H Ziegler
Journal: Eur J Clin Pharmacol Date: 1988 Impact factor: 2.953

GABA receptors are increased in brains of alcoholics.

Review 1. Neuroimaging insights into the role of cortical GABA systems and the influence of nicotine on the recovery from alcohol dependence.

2. Quantitative trait loci involved in genetic predisposition to acute alcohol withdrawal in mice.

3. Advances in understanding alcohol withdrawal states.

4. Reduced motor cortex GABA_BR function following chronic alcohol exposure.

5. Effects of GABAergic agonists and antagonists on various ethanol-induced behavioral changes.

6. A comparison of the amnesic effects of lorazepam in alcoholics and non-alcoholics.

7. A comparison of the effect of lorazepam on memory in heavy and low social drinkers.

8. Benzodiazepine binding sites in alcoholic cirrhotics: evidence for gender differences.

Review 9. The role of GABA(A) receptors in the acute and chronic effects of ethanol: a decade of progress.

10. Lack of effect of the benzodiazepine antagonist flumazenil (Ro 15-1788) on the performance of healthy subjects during experimentally induced ethanol intoxication.