| Literature DB >> 6261631 |
S H Swierenga, J F Whitfield, A L Boynton, J P MacManus, R H Rixon, M Sikorska, B K Tsang, P R Walker.
Abstract
Calcium and cyclic AMP control the proliferation of nontumorigenic liver cells. These agents seem to be cogenerators of a signal to start synthesizing deoxyribonucleotides, the earliest of the DNA synthetic processes. By contrast, calcium has little or no effect on the proliferation of tumorigenic cells in vitro. Some possible reasons for this loss of control are presented, and the usefulness of this property as a tool for the detection of carcinogens is discussed.Entities:
Mesh：
Substances：
Year: 1980 PMID： 6261631 DOI： 10.1111/j.1749-6632.1980.tb29534.x
Source DB: PubMed Journal: Ann N Y Acad Sci ISSN： 0077-8923 Impact factor: 5.691