Literature DB >> 6261505

Regulation of 86Rb outflow from pancreatic islets. IV. Effect of cyclic AMP, dibutyryl-cyclic AMP and theophylline.

A R Carpinelli, W J Malaisse.   

Abstract

Theophylline (1.4 mM), cyclic AMP (1.0 mM) and dibutyryl-cyclic AMP (0.5 mM) decreased 86Rb fractional outflow rate from pancreatic islets perifused in the absence of glucose. In the presence of glucose (16.7 mM), however, the same drugs provoked a modest increase in 86Rb fractional outflow rate. The increase in 86Rb outflow evoked by theophylline in the presence of glucose was suppressed by quinine, suggesting that it may result from an increase in cytosolic Ca2+ concentration. It is proposed that changes in the cyclic AMP content of islet cells may participate in the regulation of K+ conductance by insulin secretagogues.

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Year:  1980        PMID： 6261505     DOI： 10.1007/bf02581319

Source DB:  PubMed          Journal:  Acta Diabetol Lat        ISSN： 0001-5563


  28 in total

1.  Glucose-induced changes of the membrane potential of pancreatic B-cells: their significance for the regulation of insulin release.

Authors:  H P Meissner; M Preissler
Journal:  Adv Exp Med Biol       Date:  1979       Impact factor: 2.622

2.  Effect of glucose on K+ handling by pancreatic islets.

Authors:  A C Boschero; S Kawazu; G Duncan; W J Malaisse
Journal:  FEBS Lett       Date:  1977-11-01       Impact factor: 4.124

3.  The stimulus-secretion coupling of glucose-induced insulin release. XI. Effects of theophylline and epinephrine on Ca efflux from perifused islets.

Authors:  G R Brisson; W J Malaisse
Journal:  Metabolism       Date:  1973-03       Impact factor: 8.694

4.  The stimulus-secretion coupling of glucose-induced insulin release. XLII. Effects of extracellular pH on insulin release: their dependency on nutrient concentration.

Authors:  J C Hutton; A Sener; A Herchuelz; I Valverde; A C Boschero; W J Malaisse
Journal:  Horm Metab Res       Date:  1980-07       Impact factor: 2.936

5.  The stimulus-secretion coupling of glucose-induced insulin release. XXXV. The links between metabolic and cationic events.

Authors:  W J Malaisse; J C Hutton; S Kawazu; A Herchuelz; I Valverde; A Sener
Journal:  Diabetologia       Date:  1979-05       Impact factor: 10.122

6.  Similarities in the stimulus-secretion coupling mechanisms of glucose- and 2-keto acid-induced insulin release.

Authors:  J C Hutton; A Sener; A Herchuelz; I Atwater; S Kawazu; A C Boschero; G Somers; G Devis; W J Malaisse
Journal:  Endocrinology       Date:  1980-01       Impact factor: 4.736

7.  Regulation of 86Rb+ outflow from pancreatic islets. I. Reciprocal changes in the response to glucose, tetraethylammonium and quinine.

Authors:  A Carpinelli; W J Malaisse
Journal:  Mol Cell Endocrinol       Date:  1980-02       Impact factor: 4.102

8.  Stimulus-secretion coupling of glucose-induced insulin release. XXIX. Regulation of 86Rb+ efflux from perfused islets.

Authors:  A C Boschero; W J Malaisse
Journal:  Am J Physiol       Date:  1979-02

9.  The stimulus-secretion coupling of glucose-induced insulin release. Does glycolysis control calcium transport in the B-cell?

Authors:  A Sener; J Levy; W J Malaisse
Journal:  Biochem J       Date:  1976-06-15       Impact factor: 3.857

10.  The stimulus-secretion coupling of glucose-induced insulin release. VII. A proposed site of action for adenosine-3',5'-cyclic monophosphate.

Authors:  G R Brisson; F Malaisse-Lagae; W J Malaisse
Journal:  J Clin Invest       Date:  1972-02       Impact factor: 14.808
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  2 in total

Review 1.  The role of cyclic AMP in insulin release.

Authors:  W J Malaisse; F Malaisse-Lagae
Journal:  Experientia       Date:  1984-10-15

2.  The stimulus-secretion coupling of glucose-induced insulin release. Environmental influences on L-glutamine oxidation in pancreatic islets.

Authors:  A Sener; F Malaisse-Lagae; W J Malaisse
Journal:  Biochem J       Date:  1982-02-15       Impact factor: 3.857
  2 in total

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