Literature DB >> 6261329

Regulation of plasma cholesterol by lipoprotein receptors.

M S Brown, P T Kovanen, J L Goldstein.   

Abstract

The lipoprotein transport system holds the key to understanding the mechanisms by which genes, diet, and hormones interact to regulate the plasma cholesterol level in man. Crucial components of this system are lipoprotein receptors in the liver and extrahepatic tissues that mediate the uptake and degradation of cholesterol-carrying lipoproteins. The number of lipoprotein receptors, and hence the efficiency of disposal of plasma cholesterol, can be increased by cholesterol-lowering drugs. Regulation of lipoprotein receptors can be exploited pharmacologically in the therapy of hypercholesterolemia and atherosclerosis is man.

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Year:  1981        PMID： 6261329     DOI： 10.1126/science.6261329

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  147 in total

1.  Short- and long-term effects of lovastatin and pravastatin alone and in combination with cholestyramine on serum lipids, lipoproteins and apolipoproteins in primary hypercholesterolaemia.

Authors:  B G Jacob; W Möhrle; W O Richter; P Schwandt
Journal:  Eur J Clin Pharmacol       Date:  1992       Impact factor: 2.953

2.  Uptake and degradation of filamentous actin and vitamin D-binding protein in the rat.

Authors:  S Dueland; M S Nenseter; C A Drevon
Journal:  Biochem J       Date:  1991-02-15       Impact factor: 3.857

3.  Common and rare single nucleotide polymorphisms in the LDLR gene are present in a black South African population and associate with low-density lipoprotein cholesterol levels.

Authors:  Tertia van Zyl; Johann C Jerling; Karin R Conradie; Edith J M Feskens
Journal:  J Hum Genet       Date:  2013-11-28       Impact factor: 3.172

4.  Absence of an effect of vitamin E on protein and lipid radical formation during lipoperoxidation of LDL by lipoxygenase.

Authors:  Douglas Ganini; Ronald P Mason
Journal:  Free Radic Biol Med       Date:  2014-08-01       Impact factor: 7.376

5.  Ammonium inhibits processing and cytotoxicity of reovirus, a nonenveloped virus.

Authors:  E Maratos-Flier; M J Goodman; A H Murray; C R Kahn
Journal:  J Clin Invest       Date:  1986-10       Impact factor: 14.808

6.  The effects of dietary calcium and chlordecone on cholinesterase, triglycerides, low density lipoproteins, and cholesterol in serum of rat.

Authors:  K N Chetty; J Walker; K Brown; G W Ivie
Journal:  Arch Environ Contam Toxicol       Date:  1993-04       Impact factor: 2.804

7.  Kinetics of plasma apolipoprotein E isoforms by LC-MS/MS: a pilot study.

Authors:  Valentin Blanchard; Stéphane Ramin-Mangata; Stéphanie Billon-Crossouard; Audrey Aguesse; Manon Durand; Kevin Chemello; Brice Nativel; Laurent Flet; Maud Chétiveaux; David Jacobi; Jean-Marie Bard; Khadija Ouguerram; Gilles Lambert; Michel Krempf; Mikaël Croyal
Journal:  J Lipid Res       Date:  2018-03-14       Impact factor: 5.922

8.  Delayed clearance of very low density and intermediate density lipoproteins with enhanced conversion to low density lipoprotein in WHHL rabbits.

Authors:  T Kita; M S Brown; D W Bilheimer; J L Goldstein
Journal:  Proc Natl Acad Sci U S A       Date:  1982-09       Impact factor: 11.205

9.  Production and characterization of monoclonal antibodies to rat liver microsomal 3-hydroxy-3-methylglutaryl-coenzyme A reductase.

Authors:  R E Clark; G G Martin; M C Barton; D J Shapiro
Journal:  Proc Natl Acad Sci U S A       Date:  1982-06       Impact factor: 11.205

10.  Hormone changes during the menstrual cycle in abetalipoproteinemia: reduced luteal phase progesterone in a patient with homozygous hypobetalipoproteinemia.

Authors:  D R Illingworth; D K Corbin; E D Kemp; E J Keenan
Journal:  Proc Natl Acad Sci U S A       Date:  1982-11       Impact factor: 11.205
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