Literature DB >> 6260666

Assessment of cell-mediated immunity against coxsackievirus B3-induced myocarditis in a primate model (Papio papio).

R E Paque, C J Gauntt, T J Nealon.   

Abstract

Delayed hypersensitivity and myocarditis were induced in five baboons (Papio papio) after inoculation with myocarditic murine coxsackievirus B3 (CVB3m). By means of the [3H]thymidine incorporation assay and the agarose droplet cell migration inhibition assay, specific cell-mediated immunity was detected in all five animals against viral antigens and/or KCl-extractable soluble antigens extracted from the heart of a CVB3m-inoculated baboon. KCl-extracted antigens from normal baboon heart tissues, as well as KCl-extracted antigens from spleen or liver tissues from a CVB3m-inoculated baboon, failed to stimulate baboon peripheral blood lymphocytes or inhibit the migration of baboon peritoneal exudate cells. The appearance of dissimilar antigen(s) in extracts of heart tissues from CVB3m-inoculated baboons which did not contain infectious CVB3m parallels the appearance of novel KCl-extractable antigen(s) induced by CVB3m in murine heart tissues (Paque et al., J. Immunol. 120:1672-1678). The animal model described represents the first systematic evaluation of cell-mediated immunity in CVB3m-induced myocarditis in primates and suggests that a similar phenomenon may occur in humans.

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Year:  1981        PMID： 6260666      PMCID： PMC351806          DOI： 10.1128/iai.31.1.470-479.1981

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  23 in total

1.  Limited persistence of viral antigen in coxsackievirus B3 induced heart disease in mice.

Authors:  T G Roesing; B J Landau; R L Crowell
Journal:  Proc Soc Exp Biol Med       Date:  1979-03

2.  Assessment of cell-mediated hypersensitivity against coxsackievirus B3 viral-induced myocarditis utilizing hypertonic salt extracts of cardiac tissue.

Authors:  R E Paque; C J Gauntt; T J Nealon; M D Trousdale
Journal:  J Immunol       Date:  1978-05       Impact factor: 5.422

3.  Assessment of coxsackievirus B3 ts mutants for induction of myocarditis in a murine model.

Authors:  M D Trousdale; R E Paque; T Nealon; C J Gauntt
Journal:  Infect Immun       Date:  1979-02       Impact factor: 3.441

4.  Tumor-specific antigen solubilized by hypertonic potassium chloride.

Authors:  M S Meltzer; E J Leonard; H J Rapp; T Borsos
Journal:  J Natl Cancer Inst       Date:  1971-09       Impact factor: 13.506

5.  Generation of cytotoxic T lymphocytes during coxsackievirus B-3 infection. I. Model and viral specificity1.

Authors:  C Y Wong; J J Woodruff; J F Woodruff
Journal:  J Immunol       Date:  1977-04       Impact factor: 5.422

6.  Biological and chemical characterization of human histocompatibility antigens.

Authors:  R A Reisfeld; B D Kahan
Journal:  Fed Proc       Date:  1970 Nov-Dec

7.  Clinical manifestations of coxsackievirus infections in children.

Authors:  P Dery; M I Marks; R Shapera
Journal:  Am J Dis Child       Date:  1974-10

8.  Properties of coxsackievirus B3 variants which are amyocarditic or myocarditic for mice.

Authors:  C J Gauntt; M D Trousdale; D R LaBadie; R E Paque; T Nealon
Journal:  J Med Virol       Date:  1979       Impact factor: 2.327

9.  Cell-mediated cytotoxicity to cardiac cells of lymphocytes from patients with primary myocardial disease.

Authors:  B Jacobs; Y Matsuda; S Deodhar; E Shirey
Journal:  Am J Clin Pathol       Date:  1979-07       Impact factor: 2.493

10.  T-lymphocyte-enriched murine peritoneal exudate cells. II. Genetic control of antigen-induced T-lymphocyte proliferation.

Authors:  R H Schwartz; W E Paul
Journal:  J Exp Med       Date:  1976-03-01       Impact factor: 14.307
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  14 in total

Review 1.  Coxsackievirus infection as a trigger of cardiac autoimmunity.

Authors:  L J Wolfgram; N R Rose
Journal:  Immunol Res       Date:  1989       Impact factor: 2.829

2.  Nonspecific lymphocytic myocarditis in baboons is associated with Trypanosoma cruzi infection.

Authors:  Marcia C R Andrade; Edward J Dick; Rodolfo Guardado-Mendoza; Michaelle L Hohmann; Diana C P Mejido; John L VandeBerg; Cheryl D DiCarlo; Gene B Hubbard
Journal:  Am J Trop Med Hyg       Date:  2009-08       Impact factor: 2.345

3.  Role of antiviral antibodies in resistance against coxsackievirus B3 infection: interaction between preexisting antibodies and an interferon inducer.

Authors:  C T Cho; K K Feng; V P McCarthy; M F Lenahan
Journal:  Infect Immun       Date:  1982-08       Impact factor: 3.441

Review 4.  Intricacies of cardiac damage in coxsackievirus B3 infection: implications for therapy.

Authors:  Chandirasegaran Massilamany; Arunakumar Gangaplara; Jay Reddy
Journal:  Int J Cardiol       Date:  2014-10-18       Impact factor: 4.164

5.  Antimyocarditic activity of the guanine derivative BIOLF-70 in a coxsackievirus B3 murine model.

Authors:  C J Gauntt; H M Arizpe; J T Kung; K K Ogilvie; U O Cheriyan
Journal:  Antimicrob Agents Chemother       Date:  1985-02       Impact factor: 5.191

6.  Coxsackievirus B3 infection alters plasma membrane of neonatal skin fibroblasts.

Authors:  C W Lutton; C J Gauntt
Journal:  J Virol       Date:  1986-10       Impact factor: 5.103

7.  Coxsackievirus B3-induced myocarditis: perforin exacerbates disease, but plays no detectable role in virus clearance.

Authors:  J R Gebhard; C M Perry; S Harkins; T Lane; I Mena; V C Asensio; I L Campbell; J L Whitton
Journal:  Am J Pathol       Date:  1998-08       Impact factor: 4.307

8.  Temperature-sensitive mutant of coxsackievirus B3 establishes resistance in neonatal mice that protects them during adolescence against coxsackievirus B3-induced myocarditis.

Authors:  C J Gauntt; R E Paque; M D Trousdale; R J Gudvangen; D T Barr; G J Lipotich; T J Nealon; P S Duffey
Journal:  Infect Immun       Date:  1983-02       Impact factor: 3.441

9.  Interspecies differences in virus uptake versus cardiac function of the coxsackievirus and adenovirus receptor.

Authors:  Fabian Freiberg; Martina Sauter; Sandra Pinkert; Thirupugal Govindarajan; Joanna Kaldrack; Meghna Thakkar; Henry Fechner; Karin Klingel; Michael Gotthardt
Journal:  J Virol       Date:  2014-04-16       Impact factor: 5.103

10.  Characterization and myocarditic capabilities of coxsackievirus B3 variants in selected mouse strains.

Authors:  C J Gauntt; P T Gomez; P S Duffey; J A Grant; D W Trent; S M Witherspoon; R E Paque
Journal:  J Virol       Date:  1984-11       Impact factor: 5.103
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