Literature DB >> 6260499

Stabilization of 99mTc-pyrophosphate injection with gentisic acid.

J Ballinger, M Der, B Bowen.   

Abstract

The in vitro oxidation of 99mTc-labelled bone-scanning agents with the release of free sodium 99mTc-pertechnetate results in poor skeletal images. Gentisic acid (2,5-dihydroxy-benzoic acid), which has been used as an antioxidant to stabilize HEDP and HMDP kits, has now been shown to be an effective stabilizer for 99mTc-Pyrophosphate Injection and doses not compete for 99mTc-label.

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Year:  1981        PMID： 6260499     DOI： 10.1007/bf00253164

Source DB:  PubMed          Journal:  Eur J Nucl Med        ISSN： 0340-6997


  6 in total

1.  Phenolic compounds in the treatment of rheumatic fever. I. A study of gentisic acid derivatives.

Authors:  N E CLARKE; R E MOSHER; C N CLARKE
Journal:  Circulation       Date:  1953-02       Impact factor: 29.690

2.  Sodium gentisate in the treatment of acute rheumatic fever.

Authors:  L E SCHAEFER; I A RASHKOFF; R S MEGIBOW
Journal:  Circulation       Date:  1950-08       Impact factor: 29.690

3.  Radiation decomposition of technetium-99m radiopharmaceuticals.

Authors:  M W Billinghurst; S Rempel; B A Westendorf
Journal:  J Nucl Med       Date:  1979-02       Impact factor: 10.057

4.  In vitro stabilization of a low-tin bone-imaging agent (99mTc-Sn-HEDP) by ascorbic acid.

Authors:  A J Tofe; M D Francis
Journal:  J Nucl Med       Date:  1976-09       Impact factor: 10.057

5.  Esters of gentisic acid and their toxicities. III. Toxicities of new gentisic acid esters.

Authors:  J F NASH; F W BOPE; B V CHRISTENSEN
Journal:  J Am Pharm Assoc Am Pharm Assoc       Date:  1953-04

6.  Gentisic acid: a new stabilizer for low tin skeletal imaging agents: concise communication.

Authors:  A J Tofe; J A Bevan; M B Fawzi; M D Francis; E B Silberstein; G A Alexander; D E Gunderson; K Blair
Journal:  J Nucl Med       Date:  1980-04       Impact factor: 10.057
  6 in total
  1 in total

1.  68Ga-Labeling: Laying the Foundation for an Anti-Radiolytic Formulation for NOTA-sdAb PET Tracers.

Authors:  Henri Baudhuin; Julie Cousaert; Philippe Vanwolleghem; Geert Raes; Vicky Caveliers; Marleen Keyaerts; Tony Lahoutte; Catarina Xavier
Journal:  Pharmaceuticals (Basel)       Date:  2021-05-10
  1 in total

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