Literature DB >> 6260473

Inhibition of ovarian and testicular steroidogenesis by epidermal growth factor.

A J Hsueh, T H Welsh, P B Jones.   

Abstract

Epidermal growth factor (EGF), but not fibroblast growth factor, inhibits the gonadotropin stimulation of estrogen and testosterone production by primary cultures of ovarian granulosa and testicular Leydig cells, respectively. EGF also inhibits gonadal steroidogenesis induced by cholera toxin and (Bu)2cAMP, and the inhibitory effect of EGF is not associated with cell proliferation. EGF may play an important endocrine role in the regulation of steroidogenic functions of gonadal cells.

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Year:  1981        PMID： 6260473     DOI： 10.1210/endo-108-5-2002

Source DB:  PubMed          Journal:  Endocrinology        ISSN： 0013-7227            Impact factor:   4.736


  11 in total

1.  Association between EGF +61A/G polymorphism and gastric cancer in Caucasians.

Authors:  Ana Paula Araújo; Bruno M Costa; Ana L Pinto-Correia; Maria Fragoso; Paula Ferreira; Mário Dinis-Ribeiro; Sandra Costa; Rui M Reis; Rui Medeiros
Journal:  World J Gastroenterol       Date:  2011-01-28       Impact factor: 5.742

Review 2.  Growth factors in the ovary.

Authors:  G Giordano; A Barreca; F Minuto
Journal:  J Endocrinol Invest       Date:  1992-10       Impact factor: 4.256

3.  Effect of cell purity, cell concentration, and incubation conditions on rat testis Leydig cell steroidogenesis.

Authors:  D R Abayasekara; L O Kurlak; A M Band; M H Sullivan; B A Cooke
Journal:  In Vitro Cell Dev Biol       Date:  1991-03

4.  Epidermal growth factor stimulates testosterone production of human Leydig cells in vitro.

Authors:  V Syed; S A Khan; E Nieschlag
Journal:  J Endocrinol Invest       Date:  1991-02       Impact factor: 4.256

5.  The influence of gonadotropic hormones on the EGF receptor regulation in the rat ovary.

Authors:  J W Siebers; T Bauknecht; A Schopfer; M Breckwoldt
Journal:  J Endocrinol Invest       Date:  1985-10       Impact factor: 4.256

6.  Transforming growth factor-α inhibition of luteinizing hormone-stimulated androgen production by ovarian theca-interstitial cells: mechanism of action.

Authors:  S R Weitsman; D A Magoffin
Journal:  Endocrine       Date:  1995-06       Impact factor: 3.633

7.  Epidermal growth factor (EGF) receptor localization in cultured human granulosa lutein cells and the stimulation of progesterone production by EGF and transforming growth factor-alpha (TGF-alpha).

Authors:  F R Tekpetey; S A Daniel; A Yuzpe
Journal:  J Assist Reprod Genet       Date:  1995-11       Impact factor: 3.412

Review 8.  Discovery of prognostic factors for diagnosis and treatment of epithelial-derived ovarian cancer from laying hens.

Authors:  Whasun Lim; Gwonhwa Song
Journal:  J Cancer Prev       Date:  2013-09

9.  Epidermal growth factor regulates the development of stem and progenitor Leydig cells in rats.

Authors:  Xiaoheng Li; Yiyan Wang; Qiqi Zhu; Kaiming Yuan; Zhijian Su; Fei Ge; Ren-Shan Ge; Yadong Huang
Journal:  J Cell Mol Med       Date:  2020-05-22       Impact factor: 5.310

10.  Expression of Insulin-Like Growth Factor 1 (IGF-1) and Epidermal Growth Factor (EGF) Receptors and the Effect of IGF-1 and EGF on Androgen and Estrogen Release in the Myometrium of Pigs-In Vitro Study.

Authors:  Ewa Monika Waszkiewicz; Wiktoria Kozlowska; Agata Zmijewska; Anita Franczak
Journal:  Animals (Basel)       Date:  2020-05-25       Impact factor: 2.752
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