Literature DB >> 6260297

Selective neurotoxic action of capsaicin on glomerular C-type terminals in rat substantia gelatinosa.

N N Palermo, H K Brown, D L Smith.   

Abstract

This study demonstrates that capsaicin exerts a selective neurotoxic action to induce degeneration of glomerular C-type nerve terminals in adult rats. Since the C terminals may be essential components of the circuitry for modulation of pain, it is suggested that capsaicin induced analgesia is the result of this neurotoxic action.

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Year:  1981        PMID： 6260297     DOI： 10.1016/0006-8993(81)90585-0

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  7 in total

1.  Collateral sprouting of uninjured primary afferent A-fibers into the superficial dorsal horn of the adult rat spinal cord after topical capsaicin treatment to the sciatic nerve.

Authors:  R J Mannion; T P Doubell; R E Coggeshall; C J Woolf
Journal:  J Neurosci       Date:  1996-08-15       Impact factor: 6.167

Review 2.  The vanilloid agonist resiniferatoxin for interventional-based pain control.

Authors:  Michael J Iadarola; Andrew J Mannes
Journal:  Curr Top Med Chem       Date:  2011       Impact factor: 3.295

3.  Early morphological changes of primary afferent neurons and their processes in newborn mice after treatment with capsaicin.

Authors:  A Hiura; H Ishizuka
Journal:  Exp Brain Res       Date:  1994       Impact factor: 1.972

4.  Evidence for a capsaicin-sensitive vasomotor mechanism in the ventral medullary chemosensitive area of the cat.

Authors:  G Jancsó; G Such
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1985-03       Impact factor: 3.000

5.  Capsaicin and nociception in the rat and mouse. Possible role of substance P.

Authors:  R Gamse
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1982-09       Impact factor: 3.000

6.  Central terminals of capsaicin-sensitive primary afferent make synaptic contacts with neuronal soma in the mouse substantia gelatinosa.

Authors:  A Hiura; H Ishizuka
Journal:  Experientia       Date:  1995-06-14

7.  Desensitization to substance P following intrathecal injection. A technique for investigating the role of substance P in nociception.

Authors:  J Sawynok; G Robertson
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1985-11       Impact factor: 3.000
  7 in total

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