Literature DB >> 626001

Metabolism of methylmercuric chloride by the gastro-intestinal flora of the rat.

I R Rowland, M J Davies, P Grasso.   

Abstract

1. The contents of the caecum and small intestine of the rat metabolized methylmercuric chloride in vitro to a volatile product over a period of 3 to 4 days. The bacterial flora of the gut were responsible for the metabolism. 2. in the presence of caecal contents methylmercury was reduced to metallic mercury. 3. The contents of the small intestine metabolized methylmercuric chloride indirectly, as a result of prior synthesis of H2S to a volatile sulphur derivative of methylmercury.

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Year:  1978        PMID: 626001     DOI: 10.3109/00498257809060381

Source DB:  PubMed          Journal:  Xenobiotica        ISSN: 0049-8254            Impact factor:   1.908


  9 in total

1.  The effect of various dietary fibres on tissue concentration and chemical form of mercury after methylmercury exposure in mice.

Authors:  I R Rowland; A K Mallett; J Flynn; R J Hargreaves
Journal:  Arch Toxicol       Date:  1986-07       Impact factor: 5.153

2.  Editor's Highlight: Variation in Methylmercury Metabolism and Elimination Status in Humans Following Fish Consumption.

Authors:  Samuel W Caito; Brian P Jackson; Tracy Punshon; Thomas Scrimale; Alex Grier; Steven R Gill; Tanzy M Love; Gene E Watson; Edwin van Wijngaarden; Matthew D Rand
Journal:  Toxicol Sci       Date:  2018-02-01       Impact factor: 4.849

Review 3.  Internal Dynamics and Metabolism of Mercury in Biota: A Review of Insights from Mercury Stable Isotopes.

Authors:  Mi-Ling Li; Sae Yun Kwon; Brett A Poulin; Martin Tsz-Ki Tsui; Laura C Motta; Moonkyoung Cho
Journal:  Environ Sci Technol       Date:  2022-06-19       Impact factor: 11.357

4.  Transformation of mercuric chloride and methylmercury by the rumen microflora.

Authors:  S Kozak; C W Forsberg
Journal:  Appl Environ Microbiol       Date:  1979-10       Impact factor: 4.792

5.  Variation in Methylmercury Metabolism and Elimination in Humans: Physiological Pharmacokinetic Modeling Highlights the Role of Gut Biotransformation, Skeletal Muscle, and Hair.

Authors:  Quintin Pope; Matthew D Rand
Journal:  Toxicol Sci       Date:  2021-02-26       Impact factor: 4.849

Review 6.  Chemical transformation of xenobiotics by the human gut microbiota.

Authors:  Nitzan Koppel; Vayu Maini Rekdal; Emily P Balskus
Journal:  Science       Date:  2017-06-23       Impact factor: 47.728

7.  Drosophotoxicology: Elucidating Kinetic and Dynamic Pathways of Methylmercury Toxicity in a Drosophila Model.

Authors:  Matthew D Rand; Daria Vorojeikina; Ashley Peppriell; Jakob Gunderson; Lisa M Prince
Journal:  Front Genet       Date:  2019-08-09       Impact factor: 4.599

8.  Navigating a Two-Way Street: Metal Toxicity and the Human Gut Microbiome.

Authors:  Silke Schmidt
Journal:  Environ Health Perspect       Date:  2022-03-18       Impact factor: 9.031

Review 9.  The gut microbiota: a major player in the toxicity of environmental pollutants?

Authors:  Sandrine P Claus; Hervé Guillou; Sandrine Ellero-Simatos
Journal:  NPJ Biofilms Microbiomes       Date:  2016-05-04       Impact factor: 7.290

  9 in total

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