| Literature DB >> 6259985 |
G Sachs, T Berglindh, E Rabon, B Wallmark, M L Barcellona, H B Stewart, G Saccomani.
Abstract
The gastric H+ secretion in isolated cell requires K+ and is ATP dependent. There is also evidence in the cell system for Na+ inhibition of H+ secretion. The isolated gastric ATPase also shows K+ activation and inhibition by K+ or Na+ located on the ATP binding side of the enzyme, which corresponds to the cytoplasmic face of the enzyme. Gastric vesicles are activated in terms of transport activity by internal K+, and this site, inhibited by reagents that modify carboxyl groups, is required for enzyme turnover and transport.Entities:
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Year: 1980 PMID： 6259985 DOI： 10.1111/j.1749-6632.1980.tb15391.x
Source DB: PubMed Journal: Ann N Y Acad Sci ISSN： 0077-8923 Impact factor: 5.691