Literature DB >> 6259408

Growth regulation of fibroblasts by thrombin, factor XIII and fibronectin.

H D Bruhn, J Pohl.   

Abstract

The stimulation of fibroblast proliferation by thrombin and factor XIII is accompanied by an intracellular increase of cGMP. In contrast fibronectin inhibits the 3H-thymidine uptake of fibroblasts. Pre-treatment of fibroblasts with neuraminidase eliminates the stimulating effect of thrombin completely and induces a shift of the optimum stimulating effect of factor XIII to higher concentrations. It is discussed that thrombin and factor XIII stimulate the proliferation of fibroblasts as growth hormones and regulate in combination with the inhibiting fibronectin the growth of fibroblasts in thrombus organization, wound healing and in the arteriosclerotic vessel wall process.

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Year:  1981        PMID： 6259408     DOI： 10.1007/bf01477357

Source DB:  PubMed          Journal:  Klin Wochenschr        ISSN： 0023-2173


  5 in total

1.  The influence of fibrin stabilizing factor on the growth of fibroblasts in vitro and wound healing.

Authors:  E BECK; F DUCKERT; M ERNST
Journal:  Thromb Diath Haemorrh       Date:  1961-12-15

2.  Growth stimulation of cultured postembryonic epidermal cells by vitamin A acid.

Authors:  E Christophers
Journal:  J Invest Dermatol       Date:  1974-12       Impact factor: 8.551

3.  [The effect of the coagulation and fibrinolysis system on wound healing and thrombus organization].

Authors:  H D Bruhn; E Christophers; J Pohl
Journal:  Verh Dtsch Ges Inn Med       Date:  1978

4.  Thrombin and fibrin-induced growth of fibroblasts: role in wound repair and thrombus organization.

Authors:  J Pohl; H D Bruhn; E Christophers
Journal:  Klin Wochenschr       Date:  1979-03-15

5.  Mitogenic activity of blood components. I. Thrombin and prothrombin.

Authors:  L B Chen; J M Buchanan
Journal:  Proc Natl Acad Sci U S A       Date:  1975-01       Impact factor: 11.205
  5 in total
  9 in total

1.  Differential effects of soluble and immobilized fibronectins on aortic endothelial cell proliferation and attachment.

Authors:  J C Bowersox; N Sorgente
Journal:  In Vitro Cell Dev Biol       Date:  1987-11

2.  Characterisation of connective tissue cells containing factor XIII subunit a.

Authors:  R Adány; M A Glukhova; A Y Kabakov; L Muszbek
Journal:  J Clin Pathol       Date:  1988-01       Impact factor: 3.411

3.  Factor XIII deficiency causes cardiac rupture, impairs wound healing, and aggravates cardiac remodeling in mice with myocardial infarction.

Authors:  Matthias Nahrendorf; Kai Hu; Stefan Frantz; Farouc A Jaffer; Ching-Hsuan Tung; Karl-Heinz Hiller; Sabine Voll; Peter Nordbeck; David Sosnovik; Stefan Gattenlöhner; Mikhail Novikov; Gerhard Dickneite; Guy L Reed; Peter Jakob; Anthony Rosenzweig; Wolfgang R Bauer; Ralph Weissleder; Georg Ertl
Journal:  Circulation       Date:  2006-02-27       Impact factor: 29.690

4.  Immunohistochemical detection of factor XIIIa and factor XIIIs in synovial membranes of patients with rheumatoid arthritis or osteoarthritis.

Authors:  A Plenz; P Fritz; G König; W Laschner; J G Saal
Journal:  Rheumatol Int       Date:  1996       Impact factor: 2.631

5.  Influences of thrombin, factor XIII and fibronectin on the growth of tumor cells and leukemic cells in vitro.

Authors:  H D Bruhn; R Bernsmeier; P Lück; K H Zurborn; E Christophers
Journal:  Klin Wochenschr       Date:  1983-02-15

6.  Influences of clotting factors (thrombin, factor XIII) and of fibronectin on the growth of tumor cells and leukemic cells in vitro.

Authors:  H D Bruhn; K H Zurborn
Journal:  Blut       Date:  1983-02

7.  Fibronectin--mediator between cells and connective tissue.

Authors:  H Hörmann
Journal:  Klin Wochenschr       Date:  1982-10-15

8.  Characterization of cells containing factor XIII subunit a in benign and malignant buccal lesions.

Authors:  M Toida; Y Okumura; K K Swe Win; N Oka; T Takami; R Adány
Journal:  Histochem J       Date:  1995-06

9.  Involvement of blood coagulation factor XIII in burn healing in the carbon tetrachloride-induced hepatic injury model in rats.

Authors:  T Ogawa; Y Morioka; T Inoue; M Takano; S Tsuda
Journal:  Inflamm Res       Date:  1995-06       Impact factor: 4.575
  9 in total

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