Literature DB >> 6259113

Prophylaxis of kanamycin-induced ototoxicity by a radioprotectant.

M G Pierson, A R Møller.   

Abstract

S-2 (3-aminopropylamino)ethylphosphorothioate ameliorates hearing losses due to ototoxic doses of kanamycin sulfate in the guinea pig when administered one hour before the antibiotic. Since this radioprotectant is believed to operate as a free-radical scavenger, kanamycin ototoxicity may involve free radicals.

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Year:  1981        PMID： 6259113     DOI： 10.1016/0378-5955(81)90037-x

Source DB:  PubMed          Journal:  Hear Res        ISSN： 0378-5955            Impact factor:   3.208


  2 in total

1.  Specific glutathione-SH inhibition of toxic effects of metabolized gentamicin on isolated guinea pig hair cells.

Authors:  H P Zenner; S Keiner; U Zimmermann
Journal:  Eur Arch Otorhinolaryngol       Date:  1994       Impact factor: 2.503

2.  Generation of highly-reactive oxygen species is closely related to hair cell damage in rat organ of Corti treated with gentamicin.

Authors:  Y H Choung; A Taura; K Pak; S J Choi; M Masuda; A F Ryan
Journal:  Neuroscience       Date:  2009-03-24       Impact factor: 3.590
  2 in total

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