Literature DB >> 6258945

Vascular smooth muscle contraction initiated by postsynaptic alpha 2-adrenoceptor activation is induced by an influx of extracellular calcium.

J C Van Meel, A De Jonge, H O Kalkman, B Wilffert, P B Timmermans, P A Van Zwieten.   

Abstract

Vasoconstriction in pithed, normotensive rats elicited via stimulation of postsynaptic alpha 2-adrenoceptors by B-HT 920 was antagonized by EDTA and the calcium antagonists nifedipine, D 600 and verapamil, whereas pressor responses to the alpha 1-agonist methoxamine were unaffected. This indicates that vasoconstriction in vivo initiated via postsynaptic alpha 2-adrenoceptors requires an influx of extracellular calcium. Thus, the antihypertensive effect of calcium antagonists may be based upon a diminution of vascular tone maintained by postsynaptic alpha 2-adrenoceptors.

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Year:  1981        PMID： 6258945     DOI： 10.1016/0014-2999(81)90415-5

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  33 in total

1.  The effect of Bay K 8644 on contraction mediated by alpha-adrenoceptors in the rat saphenous vein.

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Journal:  Br J Pharmacol       Date:  1985-06       Impact factor: 8.739

2.  Alpha 2-adrenoceptor agonists enhance vasoconstrictor responses to alpha 1-adrenoceptor agonists in the rat tail artery by increasing the influx of Ca2+.

Authors:  X H Xiao; M J Rand
Journal:  Br J Pharmacol       Date:  1989-11       Impact factor: 8.739

Review 3.  Pharmacology of acute effort angina.

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4.  Influence of respiratory acidosis or alkalosis on pressor responses mediated by alpha 1- and alpha 2-adrenoceptors in pithed normotensive rats.

Authors:  C Korstanje; M J Mathy; K van Charldorp; A de Jonge; P A van Zwieten
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1985-09       Impact factor: 3.000

5.  Selective alpha 1- and alpha 2-adrenoceptor agonist-induced contractions and 45Ca fluxes in the rat isolated aorta.

Authors:  T Godfraind; R C Miller; J S Lima
Journal:  Br J Pharmacol       Date:  1982-12       Impact factor: 8.739

6.  Diltiazem and verapamil: functional antagonism of exogenous noradrenaline and angiotensin II in man.

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7.  Cardiopulmonary effects of xylazine and yohimbine in laterally recumbent sheep.

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8.  Organic and inorganic calcium antagonists reduce vasoconstriction in vivo mediated by postsynaptic alpha 2-adrenoceptors.

Authors:  J C Van Meel; A de Jonge; H O Kalkman; B Wilffert; P B Timmermans; P A van Zwieten
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1981-07       Impact factor: 3.000

9.  Dexmedetomidine-induced decrease in cerebral blood flow is attenuated by verapamil in rats: a laser Doppler study.

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Journal:  Can J Anaesth       Date:  1993-08       Impact factor: 5.063

10.  Studies on the anti-vasoconstrictor activity of BRL 34915 in spontaneously hypertensive rats; a comparison with nifedipine.

Authors:  R E Buckingham
Journal:  Br J Pharmacol       Date:  1988-03       Impact factor: 8.739
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