Literature DB >> 6258928

Opiate and peptide interaction: effect of enkephalins on morphine analgesia.

N M Lee, L Leybin, J K Chang, H H Loh.   

Abstract

Interactions between the weakly analgesic enkephalins and morphine on morphine-induced analgesia were studied. Met-enkephalin exhibited morphine analgesia whereas Leu-enkephalin potentiated it. Both Met- and Leu-enkephalin, when tested alone, were not analgesic. The strongly analgesic FK33824 (Sandoz) compound, like Leu-enkephalin, also potentiated morphine analgesia. Tolerance developed to morphine analgesia but not to Met-enkephalin inhibition of morphine analgesia.

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Year:  1980        PMID： 6258928     DOI： 10.1016/0014-2999(80)90319-2

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  16 in total

1.  Relationship between endogenous opioid function and opioid analgesic adverse effects.

Authors:  Rajnish K Gupta; Stephen Bruehl; John W Burns; Asokumar Buvanendran; Melissa Chont; Erik Schuster; Christopher R France
Journal:  Reg Anesth Pain Med       Date:  2014 May-Jun       Impact factor: 6.288

Review 2.  Development of delta opioid peptides as nonaddicting analgesics.

Authors:  R S Rapaka; F Porreca
Journal:  Pharm Res       Date:  1991-01       Impact factor: 4.200

Review 3.  Heteromers of μ-δ opioid receptors: new pharmacology and novel therapeutic possibilities.

Authors:  Wakako Fujita; Ivone Gomes; Lakshmi A Devi
Journal:  Br J Pharmacol       Date:  2014-07-01       Impact factor: 8.739

4.  Potentiation of pentazocine analgesia by low-dose naloxone.

Authors:  J D Levine; N C Gordon; Y O Taiwo; T J Coderre
Journal:  J Clin Invest       Date:  1988-11       Impact factor: 14.808

Review 5.  Functional relevance of μ-δ opioid receptor heteromerization: a role in novel signaling and implications for the treatment of addiction disorders: from a symposium on new concepts in mu-opioid pharmacology.

Authors:  Steven D Stockton; Lakshmi A Devi
Journal:  Drug Alcohol Depend       Date:  2011-11-23       Impact factor: 4.492

6.  Mu and delta opioid receptors on nociceptors attenuate mechanical hyperalgesia in rat.

Authors:  E K Joseph; J D Levine
Journal:  Neuroscience       Date:  2010-08-22       Impact factor: 3.590

7.  Synthesis and Investigation of Mixed μ-Opioid and δ-Opioid Agonists as Possible Bivalent Ligands for Treatment of Pain.

Authors:  Ruben S Vardanyan; James P Cain; Saghar Mowlazadeh Haghighi; Vlad K Kumirov; Mary I McIntosh; Alexander J Sandweiss; Frank Porreca; Victor J Hruby
Journal:  J Heterocycl Chem       Date:  2016-06-01       Impact factor: 2.193

8.  In vivo activation of a mutant mu-opioid receptor by naltrexone produces a potent analgesic effect but no tolerance: role of mu-receptor activation and delta-receptor blockade in morphine tolerance.

Authors:  Sabita Roy; Xiaohong Guo; Jennifer Kelschenbach; Yuxiu Liu; Horace H Loh
Journal:  J Neurosci       Date:  2005-03-23       Impact factor: 6.167

9.  Production of antinociception by peripheral administration of [Lys7]dermorphin, a naturally occurring peptide with high affinity for mu-opioid receptors.

Authors:  L Negri; R Lattanzi; P Melchiorri
Journal:  Br J Pharmacol       Date:  1995-01       Impact factor: 8.739

10.  Interaction between the mu-agonist dermorphin and the delta-agonist [D-Ala2, Glu4]deltorphin in supraspinal antinociception and delta-opioid receptor binding.

Authors:  L Negri; G Improta; R Lattanzi; R L Potenza; F Luchetti; P Melchiorri
Journal:  Br J Pharmacol       Date:  1995-12       Impact factor: 8.739
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