| Literature DB >> 6258761 |
M Ishida, Y Seino, T Simotsuji, T Ishii, K Yamaoka, T Harada, H yabuuchi, K Nishimura.
Abstract
Changes in the plasma and urinary adenosine 3', 5' monophosphate (cyclic AMP) levels on infusion of parathyroid hormone were studied in 10 normal children, 5 children with idiopathic hypoparathyroidism, and 3 children with pseudohypoparathyroidism. In normal children the plasma concentration of cyclic AMP ranges from 18.0 to 68.0 pmoles/ml under basal conditions, and increases to a peak of about 10-fold the basal level 5 min after infusion of parathyroid hormone. Infusion of parathyroid hormone caused no increase in plasma cyclic AMP in patients with pseudohypoparathyroidism but about 18-fold increase in those with idiopathic hypoparathyroidism. The measurement of plasma cyclic AMP before and 5 min after infusion of parathyroid hormone is concluded to be a single and effective method for differential diagnosis of hypoparathyroid disorders.Entities:
Mesh:
Substances:
Year: 1980 PMID: 6258761 DOI: 10.1007/bf02407182
Source DB: PubMed Journal: Calcif Tissue Int ISSN: 0171-967X Impact factor: 4.333