Literature DB >> 6258677

Decreased concentration of myocardial alpha-adrenoceptors with increasing age in foetal lambs.

J B Cheng, L E Cornett, A Goldfien, J M Roberts.   

Abstract

Using [3H]-dihydroergocryptine, we identified myocardial alpha-adrenoceptor binding sites in foetal lambs and demonstrated that the concentration of receptors decreased with increasing foetal age. The presence of the receptor in the foetus correlated with the presence of myocardial alpha-adrenergic responsiveness. However, we found neither the alpha-receptor binding site nor responsiveness to alpha-adrenoceptor stimulation in the myocardium of adult sheep.

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Year:  1980        PMID： 6258677      PMCID： PMC2044380          DOI： 10.1111/j.1476-5381.1980.tb09769.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  6 in total

1.  alpha-adrenergic receptor in rat heart. Effects of thyroidectomy.

Authors:  V K Sharma; S P Banerjee
Journal:  J Biol Chem       Date:  1978-08-10       Impact factor: 5.157

2.  A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.

Authors:  M M Bradford
Journal:  Anal Biochem       Date:  1976-05-07       Impact factor: 3.365

3.  Interactions between sympathomimetic amines and blocking agents on the rat ventricle strip.

Authors:  D G Wenzel; J L Su
Journal:  Arch Int Pharmacodyn Ther       Date:  1966-04

4.  Development of myocardial sympathetic innervation in the fetal lamb.

Authors:  E A Lebowitz; J S Novick; A M Rudolph
Journal:  Pediatr Res       Date:  1972-12       Impact factor: 3.756

5.  Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction.

Authors:  Y Cheng; W H Prusoff
Journal:  Biochem Pharmacol       Date:  1973-12-01       Impact factor: 5.858

6.  Development of cardiovascular responses to autonomic blockade in intact fetal and neonatal lambs.

Authors:  E K Vapaavouri; E A Shinebourne; R L Williams; M A Heymann; A M Rudolph
Journal:  Biol Neonate       Date:  1973
  6 in total
  1 in total

1.  Effects of gestational age and cortisol treatment on ovine fetal heart function in a novel biventricular Langendorff preparation.

Authors:  Andrew J W Fletcher; Alison J Forhead; Abigail L Fowden; Will R Ford; Peter W Nathanielsz; Dino A Giussani
Journal:  J Physiol       Date:  2004-10-28       Impact factor: 5.182
  1 in total

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