Literature DB >> 6258583

The nature of the sulphur atom liberated from xanthine oxidase by cyanide. Evidence from e.p.r. spectroscopy after 35S substitution.

J P Malthouse, R C Bray.   

Abstract

Active xanthine oxidase was labelled specifically with 33S in the cyanide-labile site of the molybdenum centre. The Very Rapid molybdenum (V) e.p.r. signal, generated from this, shows strong coupling of 33S to molybdenum, providing unambiguous evidence that, at least in the signal-giving species, this sulphur atom is a ligand of molybdenum. The structure of the signal-giving species is discussed.

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Year:  1980        PMID： 6258583      PMCID： PMC1162208          DOI： 10.1042/bj1910265

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  10 in total

1.  Comparison of the molybdenum centres of native and desulpho xanthine oxidase. The nature of the cyanide-labile sulphur atom and the nature of the proton-accepting group.

Authors:  S Gutteridge; S J Tanner; R C Bray
Journal:  Biochem J       Date:  1978-12-01       Impact factor: 3.857

2.  The molybdenum centre of native xanthine oxidase. Evidence for proton transfer from substrates to the centre and for existence of an anion-binding site.

Authors:  S Gutteridge; S J Tanner; R C Bray
Journal:  Biochem J       Date:  1978-12-01       Impact factor: 3.857

3.  13C hyperfine splitting of some molybdenum electron-paramagnetic-resonance signals from xanthine oxidase [proceedings].

Authors:  S J Tanner; R C Bray; F Bergmann
Journal:  Biochem Soc Trans       Date:  1978       Impact factor: 5.407

4.  Electron-paramagnetic-resonance spectroscopy of complexes of xanthine oxidase with xanthine and uric acid.

Authors:  R C Bray; M J Barber; D J Lowe
Journal:  Biochem J       Date:  1978-06-01       Impact factor: 3.857

5.  Electron paramagnetic resonance in biochemistry. Computer simulation of spectra from frozen aqueous samples.

Authors:  D J Lowe
Journal:  Biochem J       Date:  1978-06-01       Impact factor: 3.857

6.  The resolution of active and inactive xanthine oxidase by affinity chromatography.

Authors:  D Edmondson; V Massey; G Palmer; L M Beacham; G B Elion
Journal:  J Biol Chem       Date:  1972-03-10       Impact factor: 5.157

7.  The composition of milk xanthine oxidase.

Authors:  L I Hart; M A McGartoll; H R Chapman; R C Bray
Journal:  Biochem J       Date:  1970-03       Impact factor: 3.857

8.  On the mechanism of inactivation of xanthine oxidase by cyanide.

Authors:  V Massey; D Edmondson
Journal:  J Biol Chem       Date:  1970-12-25       Impact factor: 5.157

9.  Characterization of the molybdenum cofactor of sulfite oxidase, xanthine, oxidase, and nitrate reductase. Identification of a pteridine as a structural component.

Authors:  J L Johnson; B E Hainline; K V Rajagopalan
Journal:  J Biol Chem       Date:  1980-03-10       Impact factor: 5.157

10.  Oxygen-17 splitting of the very rapid molybdenum(V) e.p.r. signal from xanthine oxidase. Rate of exchange with water of the coupled oxygen atom.

Authors:  S Gutteridge; R C Bray
Journal:  Biochem J       Date:  1980-09-01       Impact factor: 3.857
  10 in total
  8 in total

1.  Coupling of [33S]sulphur to molybdenum(V) in different reduced forms of xanthine oxidase.

Authors:  J P Malthouse; G N George; D J Lowe; R C Bray
Journal:  Biochem J       Date:  1981-12-01       Impact factor: 3.857

2.  Reversible interconversion between sulfo and desulfo xanthine oxidase in a system containing rhodanese, thiosulfate, and sulfhydryl reagent.

Authors:  T Nishino; C Usami; K Tsushima
Journal:  Proc Natl Acad Sci U S A       Date:  1983-04       Impact factor: 11.205

3.  Pulsed electron paramagnetic resonance spectroscopy of (33)S-labeled molybdenum cofactor in catalytically active bioengineered sulfite oxidase.

Authors:  Eric L Klein; Abdel Ali Belaidi; Arnold M Raitsimring; Amanda C Davis; Tobias Krämer; Andrei V Astashkin; Frank Neese; Günter Schwarz; John H Enemark
Journal:  Inorg Chem       Date:  2014-01-03       Impact factor: 5.165

4.  The structure of the inhibitory complex of alloxanthine (1H-pyrazolo[3,4-d]pyrimidine-4,6-diol) with the molybdenum centre of xanthine oxidase from electron-paramagnetic-resonance spectroscopy.

Authors:  T R Hawkes; G N George; R C Bray
Journal:  Biochem J       Date:  1984-03-15       Impact factor: 3.857

5.  Purification and characterization of human platelet proteoglycan.

Authors:  M Okayama; K Oguri; Y Fujiwara; H Nakanishi; H Yonekura; T Kondo; N Ui
Journal:  Biochem J       Date:  1986-01-01       Impact factor: 3.857

6.  Molybdenum(V) e.p.r. signals obtained from xanthine oxidase on reduction with aldehyde substrates and with 2-amino-4-hydroxy-6-formylpteridine.

Authors:  J P Malthouse; J W Williams; R C Bray
Journal:  Biochem J       Date:  1981-08-01       Impact factor: 3.857

7.  Kinetic and e.p.r. studies on the inhibition of xanthine oxidase by alloxanthine (1 H-pyrazolo [3, 4-d] pyrimidine-4,6-diol).

Authors:  J W Williams; R C Bray
Journal:  Biochem J       Date:  1981-06-01       Impact factor: 3.857

8.  A structure-based catalytic mechanism for the xanthine oxidase family of molybdenum enzymes.

Authors:  R Huber; P Hof; R O Duarte; J J Moura; I Moura; M Y Liu; J LeGall; R Hille; M Archer; M J Romão
Journal:  Proc Natl Acad Sci U S A       Date:  1996-08-20       Impact factor: 11.205
  8 in total

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