Literature DB >> 6258429

The molecular basis of hemoglobin Grady.

A F Scott, J A Phillips, K E Young, H H Kazazian, K D Smith, S Charache, J B Clegg.   

Abstract

DNA from individuals heterozygous for the extended alpha-chain variant Hb Grady were studied by gene counting and restriction enzyme analysis. Neither method indicated the presence of an extra (fifth) alpha gene, which argues that if this variant arose by unequal crossing over, the event most likely involved mispairing between alleles rather than between the separate alpha 1 and alpha 2 loci.

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Year:  1981        PMID： 6258429      PMCID： PMC1684884     

Source DB:  PubMed          Journal:  Am J Hum Genet        ISSN： 0002-9297            Impact factor:   11.025


  12 in total

1.  Detection of specific sequences among DNA fragments separated by gel electrophoresis.

Authors:  E M Southern
Journal:  J Mol Biol       Date:  1975-11-05       Impact factor: 5.469

2.  Hb Grady and alpha thalassemia: a contribution to the problem of the number of Hb alpha structural loci in man.

Authors:  T H Huisman; A Miller
Journal:  Am J Hum Genet       Date:  1976-07       Impact factor: 11.025

3.  Analysis of human Y-chromosome-specific reiterated DNA in chromosome variants.

Authors:  L M Kunkel; K D Smith; S H Boyer; D S Borgaonkar; S S Wachtel; O J Miller; W R Breg; H W Jones; J M Rary
Journal:  Proc Natl Acad Sci U S A       Date:  1977-03       Impact factor: 11.205

4.  Hemoglobin Grady: the first example of a variant with elongated chains due to an insertion of residues.

Authors:  T H Huisman; J B Wilson; M Gravely; M Hubbard
Journal:  Proc Natl Acad Sci U S A       Date:  1974-08       Impact factor: 11.205

5.  Biosynthesis of hemoglobin Ann Arbor: evidence for catabolic and feedback regulation.

Authors:  J G Adams; W P Winter; D L Rucknagel; H H Spencer
Journal:  Science       Date:  1972-06-30       Impact factor: 47.728

6.  The duplicated human alpha globin genes lie close together in cellular DNA.

Authors:  S H Orkin
Journal:  Proc Natl Acad Sci U S A       Date:  1978-12       Impact factor: 11.205

7.  Repetitive sequences in isolated Thomas circles from Drosophila melanogaster.

Authors:  F H Schachat; D S Hogness
Journal:  Cold Spring Harb Symp Quant Biol       Date:  1974

8.  A physical map of the DNA regions flanking the rabbit beta-globin gene.

Authors:  A J Jeffreys; R A Flavell
Journal:  Cell       Date:  1977-10       Impact factor: 41.582

9.  Polymorphism of DNA sequence adjacent to human beta-globin structural gene: relationship to sickle mutation.

Authors:  Y W Kan; A M Dozy
Journal:  Proc Natl Acad Sci U S A       Date:  1978-11       Impact factor: 11.205

10.  Insertion of synthetic copies of human globin genes into bacterial plasmids.

Authors:  J T Wilson; L B Wilson; J K deRiel; L Villa-komaroff; A Efstratiadis; B G Forget; S M Weissman
Journal:  Nucleic Acids Res       Date:  1978-02       Impact factor: 16.971
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  3 in total

1.  The Atlanta family with hemoglobin Grady revisited.

Authors:  M P Cleek; M B Gardiner; A L Reese; H F Harris; A E Felice; T H Huisman
Journal:  Am J Hum Genet       Date:  1983-11       Impact factor: 11.025

Review 2.  The thalassemias: molecular mechanisms of human genetic disease.

Authors:  R A Spritz; B G Forget
Journal:  Am J Hum Genet       Date:  1983-05       Impact factor: 11.025

3.  Two new human hemoglobin variants caused by unusual mutational events: Hb Zaïre contains a five residue repetition within the alpha-chain and Hb Duino has two residues substituted in the beta-chain.

Authors:  H Wajcman; Y Blouquit; C Vasseur; A Le Querrec; M Laniece; C Melevendi; A Rasore; F Galacteros
Journal:  Hum Genet       Date:  1992-08       Impact factor: 4.132
  3 in total

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