Literature DB >> 6258394

Neuronal VIP in salivary glands: distribution and release.

R Uddman, J Fahrenkrug, L Malm, J Alumets, R Håkanson, F Sundler.   

Abstract

Nerves containing vasoactive intestinal peptide (VIP) were observed in salivary glands of rat, cat and man. VIP nerves were numerous in the cat while they were moderate in number in rat and man. The measured concentrations of immunoassayable VIP were in agreement with the immunohistochemical findings. Electrical stimulation of the feline chorda lingual nerve, which stimulates salivary secretion and local blood flow, resulted in a marked elevation of VIP in the venous effluent from the submandibular gland. VIP was not measurable in saliva. Gel permeation chromatography of extracts from cat submandibular gland and from venous plasma collected before and during nervous stimulation revealed one immunoreactive peak with an elution position identical to that of highly purified porcine VIP. The finding of neuronal VIP in salivary glands, its release upon nerve stimulation and its known effect on local blood flow support the view that VIP is a neurotransmitter in the salivary glands.

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Year:  1980        PMID： 6258394     DOI： 10.1111/j.1748-1716.1980.tb06626.x

Source DB:  PubMed          Journal:  Acta Physiol Scand        ISSN： 0001-6772


  19 in total

1.  Secretory responses in granular ducts and acini of submandibular glands in vivo to parasympathetic or sympathetic nerve stimulation in rats.

Authors:  J R Garrett; A M Suleiman; L C Anderson; G B Proctor
Journal:  Cell Tissue Res       Date:  1991-04       Impact factor: 5.249

2.  Tachykinin involvement in parasympathetic nerve-evoked salivation of the ferret.

Authors:  J Ekström; R Håkanson; B Månsson; G Tobin
Journal:  Br J Pharmacol       Date:  1988-07       Impact factor: 8.739

3.  Cutaneous blood flow and local sweating after systemic atropine administration.

Authors:  M A Kolka; L A Stephenson
Journal:  Pflugers Arch       Date:  1987-11       Impact factor: 3.657

4.  Irradiation-induced effects on the innervation of rat salivary glands: changes in enkephalin- and bombesin-like immunoreactivity in ganglionic cells and intraglandular nerve fibers.

Authors:  L Franzén; S Forsgren; H Gustafsson; R Henriksson
Journal:  Cell Tissue Res       Date:  1993-03       Impact factor: 5.249

5.  Colonic motor and vascular responses to pelvic nerve stimulation and their relation to local peptide release in the cat.

Authors:  P O Andersson; S R Bloom; J Järhult
Journal:  J Physiol       Date:  1983-01       Impact factor: 5.182

6.  Effects of stimulation of the chorda tympani in bursts on submaxillary responses in the cat.

Authors:  P O Andersson; S R Bloom; A V Edwards; J Järhult
Journal:  J Physiol       Date:  1982-01       Impact factor: 5.182

7.  The co-localisation of substance P and VIP in cholinergic-type terminals of the rat parotid gland.

Authors:  B A al-Hadithi; V Stauber; J Mitchell
Journal:  J Anat       Date:  1988-08       Impact factor: 2.610

8.  Neuropeptide Y-like immunoreactivity in rat cranial parasympathetic neurons: coexistence with vasoactive intestinal peptide and choline acetyltransferase.

Authors:  G G Leblanc; B A Trimmer; S C Landis
Journal:  Proc Natl Acad Sci U S A       Date:  1987-05       Impact factor: 11.205

9.  VIP (vasoactive intestinal polypeptide)--immunoreactive innervation of the portal vein.

Authors:  J Järhult; J Fahrenkrug; P Hellstrand; R Uddman
Journal:  Cell Tissue Res       Date:  1982       Impact factor: 5.249

Review 10.  Peptides in the mammalian cardiovascular system.

Authors:  J Wharton; S Gulbenkian
Journal:  Experientia       Date:  1987-07-15
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