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Literature DB >> 6258094

Acetylcholine esterase sensitivity to chronic administration of diphenylhydantoin and effects on cerebral enzymatic activities related to energy metabolism.

G Benzi, E Arrigoni, R Scelsi, F Marzatico, A Gorini, R F Villa.

Abstract

The effect of chronic treatment (8 months) with diphenylhydantoin (DPH) on rat brain was studied. The activity of some enzymes related to energy transduction (lactate dehydrogenase, citrate synthase, and malate dehydrogenase; NADH-cytochrome c reductase and cytochrome oxidase) and neurotransmission (acetylcholine esterase) was evaluated both in the whole brain homogenate and/or in the crude mitochondrial fraction. A clear-cut decrease of acetylcholine esterase activity was observed, the decrease continuing even after treatment was discontinued. Effects on energy metabolism and on lactate dehydrogenase, malate dehydrogenase, and cytochrome oxidase are discussed.

Entities: Chemical Gene Species

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Year: 1980 PMID： 6258094 DOI： 10.1007/bf00965790

Source DB: PubMed Journal: Neurochem Res ISSN： 0364-3190 Impact factor: 3.996

20 in total

1. Activities of citrate synthase, NAD+-linked and NADP+-linked isocitrate dehydrogenases, glutamate dehydrogenase, aspartate aminotransferase and alanine aminotransferase in nervous tissues from vertebrates and invertebrates.

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Journal: Biochem J Date: 1975-07 Impact factor: 3.857

2. The effect of diphenylhydantoin on central catecholamine containing neuronal systems.

Authors: P N Elliott; P Jenner; D Chadwick; E Reynolds; C D Marsden
Journal: J Pharm Pharmacol Date: 1977-01 Impact factor: 3.765

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4. Enzymatic activities in the senescent brain and interference with S-adenosyl-L-methionine.

Authors: G Benzi; E Arrigoni; P Strada; R F Villa
Journal: Exp Gerontol Date: 1979 Impact factor: 4.032

5. Anticonvulsant drugs.

Authors: H H MERRITT; S CARTER
Journal: Med Clin North Am Date: 1950-03 Impact factor: 5.456

6. The influences of phenytoin on the fundamental electrical properties of simple neural systems.

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7. Mechanism of action of anticonvulsants. Role of the differential effects on the active uptake of putative neurotransmitters.

Authors: J Weinberger; W J Nicklas; S Berl
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Acetylcholine esterase sensitivity to chronic administration of diphenylhydantoin and effects on cerebral enzymatic activities related to energy metabolism.

1. Activities of citrate synthase, NAD+-linked and NADP+-linked isocitrate dehydrogenases, glutamate dehydrogenase, aspartate aminotransferase and alanine aminotransferase in nervous tissues from vertebrates and invertebrates.

2. The effect of diphenylhydantoin on central catecholamine containing neuronal systems.

3. Cholinergic and non-cholinergic nerve endings in rat brain. I. Isolation and subcellular distribution of acetylcholine and acetylcholinesterase.

4. Enzymatic activities in the senescent brain and interference with S-adenosyl-L-methionine.

5. Anticonvulsant drugs.

6. The influences of phenytoin on the fundamental electrical properties of simple neural systems.

7. Mechanism of action of anticonvulsants. Role of the differential effects on the active uptake of putative neurotransmitters.

8. Motor nerve terminal and muscle membrane stabilization by diphenylhydantoin administration.

9. Effect of chronic treatment with some drugs on the enzymatic activities of the rat brain.

10. Diphenylhydantoin and potassium transport in isolated nerve terminals.

Review 1. Medication-Induced Tardive Dyskinesia: A Review and Update.

2. Effect of N'-nitrosodimethylamine on red blood cell rheology and proteomic profiles of brain in male albino rats.