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Literature DB >> 6258092

Effect of ethanol on superoxide dismutase activity in cultured neural cells.

M Ledig, J R M'Paria, J C Louis, R Fried, P Mandel.

Abstract

Superoxide dismutase (EC 1.15.1.1) activity was investigated in several types of neural cells cultivated in the presence of 100 mM ethanol. Superoxide dismutase was inhibited by acute treatment with ethanol. Chronic treatment with ethanol specifically inhibited superoxide dismutase in glial cells. In all instances withdrawal of ethanol produced a quick return to control values. Inhibition of superoxide dismutase by ethanol may increase toxic oxygen radicals in nervous tissue.

Entities: Chemical

Mesh：

Substances：

Year: 1980 PMID： 6258092 DOI： 10.1007/bf00964895

Source DB: PubMed Journal: Neurochem Res ISSN： 0364-3190 Impact factor: 3.996

18 in total

1. Increased uptake of choline by neural cell cultures chronically exposed to ethanol.

Authors: R Massarelli; P J Syapin; E P Noble
Journal: Life Sci Date: 1976-02-15 Impact factor: 5.037

2. Growth and cultivation of dissociated neurons and glial cells from embryonic chick, rat and human brain in flask cultures.

Authors: J Booher; M Sensenbrenner
Journal: Neurobiology Date: 1972

3. Enzymes catalysing ethanol metabolism in neural and somatic tissues of the rat.

Authors: N H Raskin; L Sokoloff
Journal: J Neurochem Date: 1972-02 Impact factor: 5.372

4. Isolation of hamster brain astroglia by in vitro cultivation and subcutaneous growth, and content of cerebroside, ganglioside, RNA and DNA.

Authors: H M Shein; A Britva; H H Hess; D J Selkoe
Journal: Brain Res Date: 1970-05-04 Impact factor: 3.252

Effect of ethanol on superoxide dismutase activity in cultured neural cells.

1. Increased uptake of choline by neural cell cultures chronically exposed to ethanol.

2. Growth and cultivation of dissociated neurons and glial cells from embryonic chick, rat and human brain in flask cultures.

3. Enzymes catalysing ethanol metabolism in neural and somatic tissues of the rat.

4. Isolation of hamster brain astroglia by in vitro cultivation and subcutaneous growth, and content of cerebroside, ganglioside, RNA and DNA.

5. Alcohol dehydrogenase activity in rat brain and liver.

6. Preferential neurotoxicity of pentobarbital on nerve and glial cells in culture.

7. Neuronal cells from chick embryo cerebral hemispheres cultivated on polylysine-coated surfaces.

8. Brain (NA+ + K+)-activated adenosine triphosphatase activity and neurotransmitter uptake in alcohol-dependent rats.

9. Superoxide dismutase activity in nerve cell culture.

10. Differentiated rat glial cell strain in tissue culture.

1. Combined effects of ethanol and manganese on cultured neurons and glia.

2. Effect of manganese on the development of glial cells cultured from prenatally alcohol exposed rats.

3. Superoxide dismutase activity in rat brain during acute and chronic alcohol intoxication.

Review 4. Fetal alcohol syndrome: the vulnerability of the developing brain and possible mechanisms of damage.

5. Effect of ethanol on adenosine triphosphatase and enolase activities in rat brain and in cultured nerve cells.