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Literature DB >> 6258013

Localization of the plasmid (pKM101) gene(s) involved in recA+lexA+-dependent mutagenesis.

Abstract

Twenty Tn5 insertion mutants of the drug resistance plasmid pKM101 have been isolated that are unable to enhance mutagenesis with ultraviolet (UV) irradiation or methyl methanesulfonate. By restriction mapping, the Tn5 insertion in each of these pKM101 mutants was shown to be within a 1.9 kb region of the plasmid genome. We have termed this segment of the pKM101 map the muc (mutagenesis: UV and chemical) gene(s). Characterization of these mutants indicated that any Tn5 insertion within the muc gene(s) abolished the ability of pKM101 to: (a) enhance spontaneous, UV and chemical mutagenesis, (b) increase host survival following UV-irradiation, (c) increase the survival of UV-irradiated phage plated on irradiated or unirradiated cells, and (d) suppress the repair and mutagenesis deficiencies of a umuC- mutant. Possible models to explain the role of the pKM101 muc gene(s) in mutagenesis and repair are discussed.

Entities: Chemical Species

Mesh：

Substances：

Year: 1980 PMID： 6258013 DOI： 10.1007/bf00425456

Source DB: PubMed Journal: Mol Gen Genet ISSN： 0026-8925

26 in total

1. Phage lambda receptor chromosomes for DNA fragments made with restriction endonuclease III of Haemophilus influenzae and restriction endonuclease I of Escherichia coli.

Authors: K Murray; N E Murray
Journal: J Mol Biol Date: 1975-11-05 Impact factor: 5.469

2. Uniform nomenclature for bacterial plasmids: a proposal.

Authors: R P Novick; R C Clowes; S N Cohen; R Curtiss; N Datta; S Falkow
Journal: Bacteriol Rev Date: 1976-03

3. Nomenclature of transposable elements in prokaryotes.

Authors: A Campbell; D E Berg; D Botstein; E M Lederberg; R P Novick; P Starlinger; W Szybalski
Journal: Gene Date: 1979-03 Impact factor: 3.688

4. Detection of two restriction endonuclease activities in Haemophilus parainfluenzae using analytical agarose--ethidium bromide electrophoresis.

Authors: P A Sharp; B Sugden; J Sambrook
Journal: Biochemistry Date: 1973-07-31 Impact factor: 3.162

Review 5. Ultraviolet mutagenesis and inducible DNA repair in Escherichia coli.

Authors: E M Witkin
Journal: Bacteriol Rev Date: 1976-12

6. Plasmid (pKM101)-mediated enhancement of repair and mutagenesis: dependence on chromosomal genes in Escherichia coli K-12.

Authors: G C Walker
Journal: Mol Gen Genet Date: 1977-03-28

7. Effect of host lex, recA, recF, and uvrD genotypes on the ultraviolet light-protecting and related properties of plasmid R46 in Escherichia coli.

Authors: N S Waleh; B A Stocker
Journal: J Bacteriol Date: 1979-02 Impact factor: 3.490

8. Inducible reactivation and mutagenesis of UV-irradiated bacteriophage P22 in Salmonella typhimurium LT2 containing the plasmid pKM101.

Authors: G C Walker
Journal: J Bacteriol Date: 1978-08 Impact factor: 3.490

9. Isolation and characterization of mutants of the plasmid pKM101 deficient in their ability to enhance mutagenesis and repair.

Authors: G C Walker
Journal: J Bacteriol Date: 1978-03 Impact factor: 3.490

10. Ultraviolet light protection, enhancement of ultraviolet light mutagenesis, and mutator effect of plasmid R46 in Salmonella typhimurium.

Authors: K E Mortelmans; B A Stocker
Journal: J Bacteriol Date: 1976-10 Impact factor: 3.490

31 in total

Localization of the plasmid (pKM101) gene(s) involved in recA+lexA+-dependent mutagenesis.

1. Phage lambda receptor chromosomes for DNA fragments made with restriction endonuclease III of Haemophilus influenzae and restriction endonuclease I of Escherichia coli.

2. Uniform nomenclature for bacterial plasmids: a proposal.

3. Nomenclature of transposable elements in prokaryotes.

4. Detection of two restriction endonuclease activities in Haemophilus parainfluenzae using analytical agarose--ethidium bromide electrophoresis.

Review 5. Ultraviolet mutagenesis and inducible DNA repair in Escherichia coli.

6. Plasmid (pKM101)-mediated enhancement of repair and mutagenesis: dependence on chromosomal genes in Escherichia coli K-12.

7. Effect of host lex, recA, recF, and uvrD genotypes on the ultraviolet light-protecting and related properties of plasmid R46 in Escherichia coli.

8. Inducible reactivation and mutagenesis of UV-irradiated bacteriophage P22 in Salmonella typhimurium LT2 containing the plasmid pKM101.

9. Isolation and characterization of mutants of the plasmid pKM101 deficient in their ability to enhance mutagenesis and repair.

10. Ultraviolet light protection, enhancement of ultraviolet light mutagenesis, and mutator effect of plasmid R46 in Salmonella typhimurium.

1. Genetically modified Vibrio harveyi strains as potential bioindicators of mutagenic pollution of marine environments.

2. Conjugal transfer system of the IncN plasmid pKM101.

3. LexA-independent expression of a mutant mucAB operon.

4. Cloning and mapping of the genetic determinants for microcin C51 production and immunity.

5. Two-component suppression of recF143 by recA441 in Escherichia coli K-12.

6. Spontaneous and mutagen-induced deletions: mechanistic studies in Salmonella tester strain TA102.

7. Effect of the plasmid ColIb-P9 on cellular processes related to DNA repair.

8. Inhibition of homologous recombination by the plasmid MucA'B complex.

9. New phenotypes associated with mucAB: alteration of a MucA sequence homologous to the LexA cleavage site.

10. Functional organization of plasmid pKM101.