Literature DB >> 6257675

A potent peptide affinity reagent for the opiate receptor.

R F Venn, E A Barnard.   

Abstract

The synthesis and characterization of a novel enkephalin analogue, Tyr-D-Ala-Gly-Phe-Leu-chloromethyl ketone, is described. The biological potency of the compound in various assays has been determined to be very high. The compound is an alkylating affinity reagent and irreversibly inactivates a defined population of enkephalin receptors in rat brain membrane preparations, as well as irreversibly inhibiting electrically stimulated contractions in the mouse vas deferens tissue preparation.

Entities:  

Mesh：

Substances：

Year:  1981        PMID： 6257675

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  3 in total

1.  Characterization of rat brain opioid receptors by [Tyr-3,5-3H]1, D-Ala2, Leu5-enkephalin binding.

Authors:  S Benyhe; G Tóth; J Kevei; M Szücs; A Borsodi; K Di Gléria; J Szécsi; H Süli-Vargha; K Medzihradszky
Journal:  Neurochem Res       Date:  1985-05       Impact factor: 3.996

2.  Solid Phase Synthesis and Application of Labeled Peptide Derivatives: Probes of Receptor-Opioid Peptide Interactions.

Authors:  Jane V Aldrich; Vivek Kumar; Bhaswati Dattachowdhury; Angela M Peck; Xin Wang; Thomas F Murray
Journal:  Int J Pept Res Ther       Date:  2008-12-01       Impact factor: 1.931

3.  Highly selective photoaffinity labeling of mu and delta opioid receptors.

Authors:  C Garbay-Jaureguiberry; A Robichon; V Daugé; P Rossignol; B P Roques
Journal:  Proc Natl Acad Sci U S A       Date:  1984-12       Impact factor: 11.205
  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.