| Literature DB >> 6256478 |
R N Pittman, K P Minneman, P B Molinoff.
Abstract
The densities of beta 1 and beta 2-adrenergic receptors were determined in homogenates of cerebral cortex and cerebellum of rats between 3 and 14 mo of age. No change in either receptor population occurred in the cortex during this period. In the cerebellum, a 20--25% decrease in the density of beta 2 receptors and a 350% increase in the density of beta 1 receptors occurred. The increase in beta 1 receptors in the cerebellum may be the result of a decrease in the function of the noradrenergic projections from the locus coeruleus which synapse on cerebellar Purkinje cells.Entities:
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Year: 1980 PMID： 6256478 DOI： 10.1111/j.1471-4159.1980.tb12517.x
Source DB: PubMed Journal: J Neurochem ISSN： 0022-3042 Impact factor: 5.372