Literature DB >> 6256203

Evidence against a role of (Na+ + K+)-ATPase in the alpha-adrenoceptor mediated positive inotropic effect of phenylephrine.

W Schmitz, H Scholz, E Erdmann, K Werdan.   

Abstract

Phenylephrine (0.1-100 microM) in the presence of 1 microM propranolol increased the force of contraction in electrically driven papillary muscles from cats. This presumably alpha-adrenoceptor mediated positive inotropic effect of phenylephrine occurred without any influence on (Na+ + K+)-ATPase activity.

Entities:  

Mesh：

Substances：

Year:  1980        PMID： 6256203     DOI： 10.1007/bf01969609

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  14 in total

1.  Studies on the positive inotropic effect of phenylephrine: a comparison with isoprenaline.

Authors:  F Ledda; P Marchetti; A Mugelli
Journal:  Br J Pharmacol       Date:  1975-05       Impact factor: 8.739

Review 2.  Membrane adenosinetriphosphatase: a digitalis receptor?

Authors:  T Akera
Journal:  Science       Date:  1977-11-11       Impact factor: 47.728

Review 3.  Cyclic AMP and contractile activity in heart.

Authors:  R W Tsien
Journal:  Adv Cyclic Nucleotide Res       Date:  1977

4.  Influence of temperature and frequency on the positive inotropic action of phenylephrine in the isolated rabbit papillary muscle.

Authors:  M Endoh; B Hillen; H J Schümann
Journal:  Arch Int Pharmacodyn Ther       Date:  1977-08

5.  Positive inotropic but no relaxant effects of phenylephrine in cat papillary muscle.

Authors:  T Meinertz; B Schmelzle; H Scholz
Journal:  J Cyclic Nucleotide Res       Date:  1978-08

6.  The positive inotropic effect of phenylephrine in the presence of propranolol. Increase in time to peak force and in relaxation time without increase in c-AMP.

Authors:  R Brückner; I Hackbarth; T Meinertz; B Schmelzle; H Scholz
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1978-07       Impact factor: 3.000

7.  Interactions of phenylephrine and theophylline in contractility and excitability of isolated rabbit left atria.

Authors:  H Hamakawa; T Shimizu; N Toda
Journal:  Jpn J Pharmacol       Date:  1973-06

8.  The (Na + + K + )-ATPase activity of guinea pig heart muscle in potassium deficiency.

Authors:  E Erdmann; H D Bolte; B Lüderitz
Journal:  Arch Biochem Biophys       Date:  1971-07       Impact factor: 4.013

9.  Possible role of cyclic AMP in the relaxation process of mammalian heart: effects of dibutyryl cyclic AMP and theophylline on potassium contractures in cat papillary muscles.

Authors:  T Meinertz; H Nawrath; H Scholz
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1976-05       Impact factor: 3.000

10.  Sodium influx rate and ouabain-sensitive rubidium uptake in isolated guinea pig atria.

Authors:  S Yamamoto; T Akera; T M Brody
Journal:  Biochim Biophys Acta       Date:  1979-08-07
View more
  1 in total

1.  Some characteristics of the inotropic effects of histamine H1- and H2-receptor agonists in comparison with those of alpha- and beta-adrenoceptor agonists.

Authors:  L Mantelli; S Amerini; A Picchi; A Mugelli; F Ledda
Journal:  Agents Actions       Date:  1982-04
  1 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.