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Literature DB >> 6255482

Facilitation of membrane electrical excitability in Drosophila.

Abstract

Prior electrical activity in the indirect flight muscles of Drosophila facilitates membrane excitability. The mechanism of facilitation involves the inactivation of an early, fast, transient outward current by prior membrane depolarizaton. In the facilitated state the calcium-dependent spike-like response has a decreased current and voltage threshold. The facilitated state persists for 1.5 sec after a membrane active response. A single nerve-driven spike is sufficient to facilitate membrane excitability.

Entities: Chemical Species

Mesh：

Substances：
Calcium

Year: 1980 PMID： 6255482 PMCID： PMC350246 DOI： 10.1073/pnas.77.10.6216

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

12 in total

7. Further studies of activation-inactivation coupling in Myxicola axons. Insensitivity to changes in calcium concentration.

Authors: C L Schauf; F A Davis
Journal: Biophys J Date: 1975-11 Impact factor: 4.033

Facilitation of membrane electrical excitability in Drosophila.

1. Voltage dependence of agonist effectiveness at the frog neuromuscular junction: resolution of a paradox.

2. Temperature-induced seizure and frequency-dependent neuromuscular block in a ts mutant of Drosophila.

3. Modulation of the excitatory synaptic response by fast transient K+ current in snail neurones.

4. Voltage clamp studies of a transient outward membrane current in gastropod neural somata.

5. Prediction of repetitive firing behaviour from voltage clamp data on an isolated neurone soma.

6. Calcium-dependent depression of a late outward current in snail neurons.

7. Further studies of activation-inactivation coupling in Myxicola axons. Insensitivity to changes in calcium concentration.

8. Properties of a facilitating calcium current in pace-maker neurones of the snail, Helix pomatia.

9. Three pharmacologically distinct potassium channels in molluscan neurones.

10. Behavior of delayed current under voltage clamp in the supramedullary neurons of puffer.

1. Characterization of three types of potassium current in cultured neurones of rat supraoptic nucleus area.

2. Single transient K channels in mammalian sensory neurons.

3. Functional significance of the A-current.

4. Outward currents in voltage-clamped rat sympathetic neurones.

5. Ion currents in Drosophila flight muscles.

6. Properties of transient K+ currents and underlying single K+ channels in rat olfactory receptor neurons.