Literature DB >> 6255254

The 4-methylumbelliferone sulphate sulphatases of human tears.

T W Jordan, F Heiss, B Monk, J Nicholls.   

Abstract

The properties of human tear 4-methylumbelliferone sulphate sulphatase (EC 3.1.6.1) have been investigated. More than 80% of the enzyme activity behaved as the acidic A isoenzyme on isoelectric focusing and DEAE-cellulose ion exchange chromatography. The distribution of enzyme activity in a normal population has been investigated. The least interindividual variation was seen when enzyme activities were calculated as units per mg tears. The alpha-galactosidase, beta-N-acetylglucosaminidase and sulphatase enzyme activities in human tears varied independently of each other. The use of tear sulphatases for the detection of metachromatic leukodystrophy (McKusick 24980) is discussed.

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Year:  1980        PMID： 6255254     DOI： 10.1007/bf02312523

Source DB:  PubMed          Journal:  J Inherit Metab Dis        ISSN： 0141-8955            Impact factor:   4.982


  13 in total

1.  Sulphatases, lysosomes and disease.

Authors:  A B Roy
Journal:  Aust J Exp Biol Med Sci       Date:  1976-04

2.  The assay of arylsulphatases A and B in human urine.

Authors:  H BAUM; K S DODGSON; B SPENCER
Journal:  Clin Chim Acta       Date:  1959-05       Impact factor: 3.786

3.  Arylsulfatase of human tissue. Studies on a form of arylsulfatase B found predominantly in brain.

Authors:  R L Stevens; A L Fluharty; A R Killgrove; Y Kihara
Journal:  Biochim Biophys Acta       Date:  1977-04-12

4.  Fabry disease: diagnosis by alpha-galactosidase activities in tears.

Authors:  D L Johnson; M A Del Monte; E Cotlier; R J Desnick
Journal:  Clin Chim Acta       Date:  1975-08-18       Impact factor: 3.786

5.  Microheterogeneity of arylsulfatase A from human tissues.

Authors:  R L Stevens; A L Fluharty; A R Killgrove; H Kihara
Journal:  Biochim Biophys Acta       Date:  1976-10-11

6.  Enzymic detection of metachromatic leukodystrophy patients and heterozygotes.

Authors:  T W Jordan; B Casey; H J Weston
Journal:  N Z Med J       Date:  1977-05-11

7.  Hexosaminidase A in tears and saliva for rapid identification of Tay-Sachs disease and its carriers.

Authors:  J D Singer; E Cotlier; R Krimmer
Journal:  Lancet       Date:  1973-11-17       Impact factor: 79.321

Review 8.  The clinical aspects of arylsulphatases.

Authors:  A A Farooqui; P Mandel
Journal:  Clin Chim Acta       Date:  1977-01-17       Impact factor: 3.786

9.  Purification and properties of arylsulfatase. A from human urine.

Authors:  R L Stevens; A L Fluharty; M H Skokut; H Kihara
Journal:  J Biol Chem       Date:  1975-04-10       Impact factor: 5.157

10.  Deficiencies of glucosamine-6-sulfate or galactosamine-6-sulfate sulfatases are responsible for different mucopolysaccharidoses.

Authors:  N Di Ferrante; L C Ginsberg; P V Donnelly; D T Di Ferrante; C T Caskey
Journal:  Science       Date:  1978-01-06       Impact factor: 47.728
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  1 in total

1.  Faecal sulphatase in health and in inflammatory bowel disease.

Authors:  J M Rhodes; R Gallimore; E Elias; J F Kennedy
Journal:  Gut       Date:  1985-05       Impact factor: 23.059
  1 in total

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