Literature DB >> 6254895

beta-Endorphin: radioreceptor binding assay. Relative potency of synthetic analogs with various chain lengths.

P Ferrara, C H Li.   

Abstract

An assay system is described to measure the specific binding of beta-endorphin to opiate sites (receptors) in rat brain membrane preparations using the tritiated hormone as the primary ligand. By this assay procedure, the radioreceptor activity of beta-endorphin and synthetic analogs with various chain lengths has been determined. The results suggest that both NH2- and COOH-terminal sequences of the molecule are involved in the interaction of beta-endorphin with opiate receptors.

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Year:  1980        PMID： 6254895

Source DB:  PubMed          Journal:  Int J Pept Protein Res        ISSN： 0367-8377


  3 in total

1.  Relationships among several different non-homologous polypeptide hormones.

Authors:  R M Epand
Journal:  Mol Cell Biochem       Date:  1983       Impact factor: 3.396

2.  Beta-endorphin: replacement of tyrosine in position 27 by tryptophan increases analgesic potency--preparation and properties of the 2-nitrophenylsulfenyl derivative.

Authors:  C H Li; D Yamashiro; P Nicolas
Journal:  Proc Natl Acad Sci U S A       Date:  1982-02       Impact factor: 11.205

3.  Beta-endorphin: opiate receptor binding activities of six naturally occurring beta-endorphin homologs studied by using tritiated human hormone and naloxone as primary ligands--effects of sodium ion.

Authors:  P Nicolas; R G Hammonds; C H Li
Journal:  Proc Natl Acad Sci U S A       Date:  1982-04       Impact factor: 11.205
  3 in total

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