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Literature DB >> 6254586

Involvement of a central alpha-adrenoceptor system in antidepressant potentiation of hyperthermia induced by thyrotropin releasing hormone.

Abstract

Thyrotropin releasing hormone (TRH) causes hyperthermia in mice which is potentiated by tricyclic antidepressants (nortriptyline, imipramine, clomipramine, amitriptyline), the monoamine oxidase inhibitor, tranylcypromine, and various other antidepressants (maprotiline, nomifensin, viloxazine). Only iprindole is ineffective. The effect of mianserin, itself hypothermic, could not be interpreted. A property shared by the potentiating substances seems to be activation of a central adrenoceptor system. The potentiation of TRH-induced hyperthermia which seems to be specific to antidepressants might be used in the selection of antidepressants.

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Year: 1980 PMID： 6254586 PMCID： PMC2044250 DOI： 10.1111/j.1476-5381.1980.tb07885.x

Source DB: PubMed Journal: Br J Pharmacol ISSN： 0007-1188 Impact factor: 8.739

20 in total

1. A possible common mechanism of action of antidepressant treatments: reduction in the sensitivity of the noradrenergic cyclic AMP gererating system in the rat limbic forebrain.

Authors: J Vetulani; R J Stawarz; J V Dingell; F Sulser
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1976-05 Impact factor: 3.000

1. Use of potentiation of thyrotrophin releasing hormone (TRH)-induced hyperthermia as a test for screening antidepressants which activate alpha-adrenoceptor systems.

Authors: M Desiles; R Rips
Journal: Br J Pharmacol Date: 1981-09 Impact factor: 8.739

2. The effect of highly selective inhibitors of the uptake of noradrenaline or 5-hydroxytryptamine on TRH-induced hyperthermia in mice.

Authors: L Pawłowski; H Kwiatek
Journal: Psychopharmacology (Berl) Date: 1983 Impact factor: 4.530

3. Potentiation by TRH of the effect of imipramine on the forced-swimming test.

Authors: V Reny-Palasse; R Rips
Journal: Br J Pharmacol Date: 1985-06 Impact factor: 8.739

3 in total

Involvement of a central alpha-adrenoceptor system in antidepressant potentiation of hyperthermia induced by thyrotropin releasing hormone.

1. A possible common mechanism of action of antidepressant treatments: reduction in the sensitivity of the noradrenergic cyclic AMP gererating system in the rat limbic forebrain.

2. Effect of iprindole on norepinephrine turnover and transport.

3. Blockade of noradrenaline uptake by 34276-Ba, a new antidepressant drug.

4. Enhancement of cerebral noradrenaline turnover by thyrotropin-releasing hormone.

5. Evaluation of thyrotropin-releasing hormone as a potential antidepressant agent in the conscious dog.

6. TRH potentiates behavioural changes following increased brain 5-hydroxytryptamine accumulation in rats.

7. Nomifensine: a new potent inhibitor of dopamine uptake into synaptosomes from rat brain corpus striatum.

8. Thyrotropin-releasing hormone (TRH)-induced hyperthermia and behavioral excitation in rabbits.

9. Thyrotropin releasing hormone (TRH): DOPA potentiation and biogenic amine studies.

10. Methylphenidate-like effects of the new antidepressant drug nomifensine (HOE 984).

1. Use of potentiation of thyrotrophin releasing hormone (TRH)-induced hyperthermia as a test for screening antidepressants which activate alpha-adrenoceptor systems.

2. The effect of highly selective inhibitors of the uptake of noradrenaline or 5-hydroxytryptamine on TRH-induced hyperthermia in mice.

3. Potentiation by TRH of the effect of imipramine on the forced-swimming test.