Effect of inactivator(s) formed from copper and phenol impurity(ies) on the sedimentation rate of transfective poliovirion RNA.

Transfective poliovirion RNA after inactivation by the inactivator or inactivators formed from copper and an impurity or impurities in reagent-grade phenol sediments more heterogeneously and, on the average, more slowly than intact transfective RNA. The data are consistent with the hypothesis that the inactivator causes scission of the viral RNA molecules.