Literature DB >> 6254438

C-6 glioma growth in rats: suppression with a beta-adrenergic agonist and a phosphodiesterase inhibitor.

E Chelmicka-Schorr, B G Arnason, S J Holshouser.   

Abstract

Rat C-6 glioma possesses a beta-adrenergic receptor which, when activated, raises intracellular levels of cyclic adenosine monophosphate (cAMP) in cultured C-6 glioma cells. The present study shows that growth of C-6 glioma is suppressed in rats treated with the beta-adrenergic agonist isoproterenol. Addition of papaverine, a cAMP phosphodiesterase inhibitor, to the treatment schedule augments this effect. Pharmacological agents that elevate intracellular cAMP levels may retard the growth of neural tumors in vivo.

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Year:  1980        PMID： 6254438     DOI： 10.1002/ana.410080421

Source DB:  PubMed          Journal:  Ann Neurol        ISSN： 0364-5134            Impact factor:   10.422


  3 in total

1.  Reduced beta adrenoceptor density in vivo in human lung tumours: a preliminary study with positron emission tomography.

Authors:  F Qing; M J Hayes; C G Rhodes; T Krausz; S W Fountain; M M Burke; T Jones; J M Hughes
Journal:  Thorax       Date:  1996-07       Impact factor: 9.139

2.  Imaging of a glioma using peripheral benzodiazepine receptor ligands.

Authors:  S Starosta-Rubinstein; B J Ciliax; J B Penney; P McKeever; A B Young
Journal:  Proc Natl Acad Sci U S A       Date:  1987-02       Impact factor: 11.205

Review 3.  β adrenergic receptor modulated signaling in glioma models: promoting β adrenergic receptor-β arrestin scaffold-mediated activation of extracellular-regulated kinase 1/2 may prove to be a panacea in the treatment of intracranial and spinal malignancy and extra-neuraxial carcinoma.

Authors:  George Zaki Ghali; Michael George Zaki Ghali
Journal:  Mol Biol Rep       Date:  2020-04-18       Impact factor: 2.742
  3 in total

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