Literature DB >> 6254363

The induction of immunoblastic T cell sarcomas by virus-transformed prothymocytes.

C L Reinisch, S E Kurtz, E A Morris, A Lampert.   

Abstract

The ontogeny of thymus-dependent lymphoid tumors induced by murine sarcoma-murine leukemia virus (MSV-MuLV) was investigated. Tumors that developed in spleens of infected mice 6 or more months after the injection of virus were diagnosed as immunoblastic T cell sarcomas. Cells derived from the tumors and established as a continuous cell line expressed the thymus leukemia (TL), brain-associated theta (BAT), and Qa2 cell surface antigens but lacked either the Ly 1 or Ly 2, 3 mature T cell differentiation antigens. In addition, the tumor cell expressed c type viral antigens, and had receptors for the lectin peanut agglutinin. The tumor cells were inert when tested for their capacity to respond in several functional T cell assays. Taken together, these data support the hypothesis that the primary target of malignant transformation by MSV-MuLV is a prothymocyte.

Entities:  

Mesh：

Substances：

Year:  1980        PMID： 6254363      PMCID： PMC1903601     

Source DB:  PubMed          Journal:  Am J Pathol        ISSN： 0002-9440            Impact factor:   4.307


  22 in total

1.  Target cell for oncogenic action of polycythaemia-inducing Friend virus.

Authors:  P E Tambourin; F Wendling
Journal:  Nature       Date:  1975-07-24       Impact factor: 49.962

2.  In vitro transformation of lymphoid cells by Abelson murine leukemia virus.

Authors:  N Rosenberg; D Baltimore; C D Scher
Journal:  Proc Natl Acad Sci U S A       Date:  1975-05       Impact factor: 11.205

3.  Regulation of cellular and humoral immune responses by T-cell subclasses.

Authors:  H Cantor; E A Boyse
Journal:  Cold Spring Harb Symp Quant Biol       Date:  1977

4.  A rapid method for the isolation of functional thymus-derived murine lymphocytes.

Authors:  M H Julius; E Simpson; L A Herzenberg
Journal:  Eur J Immunol       Date:  1973-10       Impact factor: 5.532

5.  Lymphosarcoma: virus-induced thymic-independent disease in mice.

Authors:  H T Abelson; L S Rabstein
Journal:  Cancer Res       Date:  1970-08       Impact factor: 12.701

6.  Ly-A and Ly-B: two systems of lymphocyte isoantigens in the mouse.

Authors:  E A Boyse; M Miyazawa; T Aoki; L J Old
Journal:  Proc R Soc Lond B Biol Sci       Date:  1968-06-11

7.  Induction and regression of primary moloney sarcoma virus-induced tumors in mice.

Authors:  A Fefer; J L McCoy; J P Glynn
Journal:  Cancer Res       Date:  1967-09       Impact factor: 12.701

8.  Suppressor cell regulation of immune response to tumors: abrogation by adult thymectomy.

Authors:  C L Reinisch; S L Andrew; S F Schlossman
Journal:  Proc Natl Acad Sci U S A       Date:  1977-07       Impact factor: 11.205

9.  Analysis of mononuclear cell surfaces with fluoresceinated staphylococcal protein A complexed with IgG antibody of heat-aggregated gamma-globulin.

Authors:  E W Ades; D J Phillips; S L Shore; D S Gordon; M G LaVia; C M Black; C B Reimer
Journal:  J Immunol       Date:  1976-12       Impact factor: 5.422

10.  Functional subclasses of T-lymphocytes bearing different Ly antigens. I. The generation of functionally distinct T-cell subclasses is a differentiative process independent of antigen.

Authors:  H Cantor; E A Boyse
Journal:  J Exp Med       Date:  1975-06-01       Impact factor: 14.307
View more
  1 in total

1.  Regulation of B cell lymphomagenesis by a malignant Qal+ inducer T cell clone.

Authors:  C L Reinisch; A P Sing; E R Bacon; R B Corley; R K Gershon
Journal:  J Exp Med       Date:  1984-03-01       Impact factor: 14.307
  1 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.