Literature DB >> 6254047

Structural organization of human genomic DNA encoding the pro-opiomelanocortin peptide.

A C Chang, M Cochet, S N Cohen.   

Abstract

We have isolated a human genomic DNA segment encoding the corticotropin-beta-lipotropin precursor peptide from a fetal DNA library, using previously cloned bovine cDNA for this peptide as a probe. The human genomic DNA was studied by electron microscope heteroduplex analysis and gel blotting methods, and its nucleotide sequence was determined and compared with that of cDNA corresponding to bovine pro-opiomelanocortin mRNA. From this sequence, segments of interspecies conservation and divergence, punctuated by pairs of the basic amino acid residues lysine and arginine, were identified. No noncoding intervening sequence was observed over an 830-base-pair DNA segment extending from a position near the 5' end of the structural pro-opiomelanocortin gene through the 3' terminus of the cDNA and including sequences for the component peptide hormones corticotropin and beta-lipotropin.

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Year:  1980        PMID： 6254047      PMCID： PMC349954          DOI： 10.1073/pnas.77.8.4890

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  35 in total

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Journal:  Biochemistry       Date:  1975-08-26       Impact factor: 3.162

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Authors:  C H Li; D Chung
Journal:  Proc Natl Acad Sci U S A       Date:  1976-04       Impact factor: 11.205

3.  Isolation, primary structure, and synthesis of alpha-endorphin and gamma-endorphin, two peptides of hypothalamic-hypophysial origin with morphinomimetic activity.

Authors:  N Ling; R Burgus; R Guillemin
Journal:  Proc Natl Acad Sci U S A       Date:  1976-11       Impact factor: 11.205

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Authors:  C H Li; D Chung
Journal:  Nature       Date:  1976-04-15       Impact factor: 49.962

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Authors:  E M Southern
Journal:  J Mol Biol       Date:  1975-11-05       Impact factor: 5.469

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Authors:  S Nakanishi; S Taii; Y Hirata; S Matsukura; H Imura
Journal:  Proc Natl Acad Sci U S A       Date:  1976-12       Impact factor: 11.205

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Authors:  A M Maxam; W Gilbert
Journal:  Proc Natl Acad Sci U S A       Date:  1977-02       Impact factor: 11.205

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Journal:  Nat New Biol       Date:  1973-07-18

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Journal:  Science       Date:  1977-04-08       Impact factor: 47.728

10.  Analysis of restriction fragments of T7 DNA and determination of molecular weights by electrophoresis in neutral and alkaline gels.

Authors:  M W McDonell; M N Simon; F W Studier
Journal:  J Mol Biol       Date:  1977-02-15       Impact factor: 5.469
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  33 in total

1.  cDNA cloning, pituitary location, and extra-pituitary expression of pro-opiomelanocortin gene in rare minnow (Gobiocypris rarus).

Authors:  Xiaohong Liu; Biwen Xie; Yaoguang Zhang; Deshou Wang; Zhijian Wang
Journal:  Fish Physiol Biochem       Date:  2010-09-29       Impact factor: 2.794

Review 2.  The Jeremiah Metzger Lecture. From POMC to functional diversity of neural peptides: the key importance of convertases.

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Journal:  Trans Am Clin Climatol Assoc       Date:  1991

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Authors:  A Ticher; D Graur
Journal:  J Mol Evol       Date:  1989-04       Impact factor: 2.395

4.  A measure of the similarity of sets of sequences not requiring sequence alignment.

Authors:  B E Blaisdell
Journal:  Proc Natl Acad Sci U S A       Date:  1986-07       Impact factor: 11.205

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Authors:  M H Kim; H J Lee; K T Min
Journal:  Appl Biochem Biotechnol       Date:  1995-01       Impact factor: 2.926

6.  Beta-turn secondary structure and melanocortin ligands.

Authors:  Erica M Haslach; Jay W Schaub; Carrie Haskell-Luevano
Journal:  Bioorg Med Chem       Date:  2008-03-04       Impact factor: 3.641

7.  In situ hybridization study of pro-opiomelanocortin (POMC) gene expression in human pituitary corticotrophs and their adenomas.

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8.  Asymmetrical distribution of CpG in an 'average' mammalian gene.

Authors:  M McClelland; R Ivarie
Journal:  Nucleic Acids Res       Date:  1982-12-11       Impact factor: 16.971

9.  In vivo regulation of the μ opioid receptor: role of the endogenous opioid agents.

Authors:  Veronica Gonzalez-Nunez; Ada Jimenez González; Katherine Barreto-Valer; Raquel E Rodríguez
Journal:  Mol Med       Date:  2013-03-05       Impact factor: 6.354

10.  Evaluation of proopiomelanocortin mRNA in the peripheral blood from patients with Cushing's syndrome of different origin.

Authors:  S Bondioni; G Mantovani; N Polentarutti; B Ambrosi; P Loli; E Peverelli; A G Lania; P Beck-Peccoz; A Spada
Journal:  J Endocrinol Invest       Date:  2007-11       Impact factor: 4.256
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