Literature DB >> 6254022

Most sequence differences between the genomes of the Akv virus and a leukemogenic Gross A virus passaged in vitro are located near the 3' terminus.

D L Buchhagen, F S Pedersen, R L Crowther, W A Haseltine.   

Abstract

The 70S genomic RNA of nonleukemogenic AKR(Akv) virus was compared to that of an in vitro passaged, cloned, leukemogenic Gross A virus by fingerprint and sequence analysis. Fifty-seven of the large ribonuclease T1-resistant oligonucleotides of each virus have the same electrophoretic mobility and sequence. Thirteen large ribonuclease T1 oligo nucleotides are unique to the Gross A virus, whereas five are unique to Akv. Four of the oligonucleotides unique to each virus are related by one or two simple base changes. Five of the differences in oligonucleotides are located in the region of the genome that codes for the gag and pol genes. Eight of the differences are located near the 3' poly(A) terminus of the virus. The origins and biological consequences of these differences are discussed.

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Year:  1980        PMID： 6254022      PMCID： PMC349834          DOI： 10.1073/pnas.77.7.4359

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  37 in total

1.  Development and serial cellfree passage of a highly potent strain of mouse leukemia virus.

Authors:  L GROSS
Journal:  Proc Soc Exp Biol Med       Date:  1957-04

Review 2.  Structure, replication, and recombination of retrovirus genomes: some unifying hypotheses.

Authors:  J M Coffin
Journal:  J Gen Virol       Date:  1979-01       Impact factor: 3.891

3.  Chromatographic Separation and Antigenic Analysis of Proteins of the Oncornaviruses IV. Biochemical Typing of Murine Viral Proteins.

Authors:  D L Buchhagen; O Stutman; E Fleissner
Journal:  J Virol       Date:  1975-05       Impact factor: 5.103

4.  Chromatographic separation and antigenic analysis of proteins of the oncornaviruses. V. Identification of a new murine viral protein, p15(E).

Authors:  H Ikeda; W Hardy; E Tress; E Fleissner
Journal:  J Virol       Date:  1975-07       Impact factor: 5.103

5.  RNase T1-resistant oligonucleotides of Akv-1 and Akv-2 type C viruses of AKR mice.

Authors:  J Rommelaere; D V Faller; N Hopkins
Journal:  J Virol       Date:  1977-11       Impact factor: 5.103

6.  An attenuated mouse leukemia virus. I. Origin and immunization.

Authors:  W H Kirsten; E Stefanski; S Panem
Journal:  J Natl Cancer Inst       Date:  1974-03       Impact factor: 13.506

7.  Presence of murine leukemia virus envelope proteins gp70 and p15(E) in a common polyprotein of infected cells.

Authors:  N G Famulari; D L Buchhagen; H D Klenk; E Fleissner
Journal:  J Virol       Date:  1976-11       Impact factor: 5.103

8.  Analysis of single- and double-stranded nucleic acids on polyacrylamide and agarose gels by using glyoxal and acridine orange.

Authors:  G K McMaster; G G Carmichael
Journal:  Proc Natl Acad Sci U S A       Date:  1977-11       Impact factor: 11.205

9.  Identification of DNA fragments carrying ecotropic proviruses of AKR mice.

Authors:  D Steffen; S Bird; W P Rowe; R A Weinberg
Journal:  Proc Natl Acad Sci U S A       Date:  1979-09       Impact factor: 11.205

10.  Leukemogenic activity of murine type C viruses after long-term passage in vitro.

Authors:  D L Buchhagen; T Pincus; O Stutman; E Fleissner
Journal:  Int J Cancer       Date:  1976-12-15       Impact factor: 7.396
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  17 in total

1.  Nucleotide sequence of the envelope gene of Friend murine leukemia virus.

Authors:  W Koch; G Hunsmann; R Friedrich
Journal:  J Virol       Date:  1983-01       Impact factor: 5.103

2.  Nucleotide sequence of the Akv env gene.

Authors:  J Lenz; R Crowther; A Straceski; W Haseltine
Journal:  J Virol       Date:  1982-05       Impact factor: 5.103

3.  Molecular cloning and analysis of the endogenous retrovirus chemically induced from RFM/Un mouse cell cultures.

Authors:  R S Liou; L R Boone; J O Kiggans; D M Yang; T W Wang; R W Tennant; W K Yang
Journal:  J Virol       Date:  1983-04       Impact factor: 5.103

4.  Leukemogenesis by Gross passage A murine leukemia virus: expression of viruses with recombinant env genes in transformed cells.

Authors:  N G Famulari; C F Koehne; P V O'Donnell
Journal:  Proc Natl Acad Sci U S A       Date:  1982-06       Impact factor: 11.205

5.  Role of recombinant ecotropic and polytropic viruses in the development of spontaneous thymic lymphomas in HRS/J mice.

Authors:  C Y Thomas; R Khiroya; R S Schwartz; J M Coffin
Journal:  J Virol       Date:  1984-05       Impact factor: 5.103

6.  Molecular cloning of a highly leukemogenic, ecotropic retrovirus from an AKR mouse.

Authors:  J Lenz; R Crowther; S Klimenko; W Haseltine
Journal:  J Virol       Date:  1982-09       Impact factor: 5.103

7.  Large RNase T1-resistant oligonucleotides encoding p15E and the U3 region of the long terminal repeat distinguish two biological classes of mink cell focus-forming type C viruses of inbred mice.

Authors:  M L Lung; J W Hartley; W P Rowe; N H Hopkins
Journal:  J Virol       Date:  1983-01       Impact factor: 5.103

8.  Structure of retroviral RNAs produced by cell lines derived from spontaneous lymphomas of AKR mice.

Authors:  F S Pedersen; R L Crowther; E F Hays; R C Nowinski; W A Haseltine
Journal:  J Virol       Date:  1982-01       Impact factor: 5.103

9.  At least two regions of the viral genome determine the oncogenic potential of avian leukosis viruses.

Authors:  H L Robinson; B M Blais; P N Tsichlis; J M Coffin
Journal:  Proc Natl Acad Sci U S A       Date:  1982-02       Impact factor: 11.205

10.  Genetic alterations of RNA leukemia viruses associated with the development of spontaneous thymic leukemia in AKR/J mice.

Authors:  C Y Thomas; J M Coffin
Journal:  J Virol       Date:  1982-08       Impact factor: 5.103
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